a long-lasting disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin produced by the body. These complications arise from glucose imbalances. They have distinct characteristics and consequences. Moreover, they also require quic...
When someone passes out from hypoglycemia, it's a medical emergency. Don't try to give them food or liquid — they could choke. You, or someone who knows how, should give them a glucagon shot — not insulin! — to raise their blood sugar to a safer level. Then call 911. An unconsc...
We studied reproducibility of GFR measurements in insulin-dependent and non-insulin-dependent diabetes mellitus patients using, respectively, a constant-infusion technique with urine collection and labeled iothalamate as a tracer marker and a single-shot procedure using Cr-EDTA, measuring the GFR from...
Genetic manipulation of cardiomyocyte insulin signaling intermediates has demonstrated that partial cardiac functional rescue can be achieved by upregulation of the insulin signaling pathway in diabetic hearts. Inconsistent findings have been reported relating to the role of cardiac AMPK and β-adrenergic ...
Usage of topicalinsulinas a healing agent in diabetic foot ulcers has grown in popularity. However, topical insulin poses a significant challenge due to the molecule's instability. Insulin is incorporated into hydrogels to ensure molecular stability and maximize its effect. ...
reduced insulin levels in people who often have elevated levels (hyperinsulinemia), which may help reduce chronic diseases like type 2 diabetes, high blood pressure, some cancers, and coronary heart disease improved levels of HDL cholesterol and triglycerides, which may reduce risk of heart disease ...
preferred to stay on the MDI therapy. We asked about the experience in using intelligent insulin pens. All the participants reported that they never saw or used these types of pens before this interview. Four participants did not welcome the idea of replacing standard insulin pens with ...
Fourteen of 27 patients (52%) were using insulin and 44% were on oral medication. Mean HbAc1 was 7.5 ± 2.4% (range 4.4–17.3%). Systemic blood pressure values were 139 ± 22 mmHg (range 105–187 mmHg) sys- tolic and 81 ± 14 mmHg (range 47–115 mmHg) diastolic. In total, 56...
Human mesenchymal stem cell derived exosomes alleviate Type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving beta-cell destruction ACS Nano, 12 (2018), pp. 7613-7628, 10.1021/acsnano.7b07643 View in ScopusGoogle Scholar Tabb et al., 2002 D.L. Tabb, W.H. McDonald...
To the contrary, suppression of Pdk4 activity could lead to reduced mitochondria-associated ER membranes (MAM) formation and improve insulin signal transduction through preventing the MAM-induced mitochondrial Ca2 + accumulation [58]. Other than the role in mediating metabolic reprogramming, Pdk4 ...