Diabetic neuropathy is not associated with homocysteine, folate, vitamin B12 levels, and MTHFR C677T mutation in type 2 diabetic outpatients taking metformin. J Endocrinol Invest 2016 Mar;39(3):305-314.Russo, G.T.; Giandalia, A.; Romeo, E.L.; Scarcella, C.; Gambadoro, N.; Zingale, ...
100 In relation to the potential therapeutic benefits of vitamin D therapy, studies are limited. An open label prospective study in 51 patients with type 2 diabetes and painful neuropathy showed that ∼2000 IU of cholecalciferol daily for 3 months resulted in an ∼50% decrease in the Visual...
diabetes, and complication. There were two types of variations of HFD, (a) high-fat diet alone or (b) high-fat diet with a combination of high-sucrose or high-fructose diet (HSHF or HFHF). These methods of induction were mainly used...
ContextDiabetic retinopathy (DR) is the leading cause of blindness in the working-aged population in the United States. There are many new interventions
The clinical history, examination and biochemical tests are required to exclude other causes of small fibre neuropathy such as vitamin B12 deficiency, alcohol-related neuropathy, genetic neuropathies, hypothyroidism, paraproteinemias, neoplasia, amyloidosis, peripheral arterial d...
neuropathy, and renal disease [7,8,9]. HO-1 expression is mainly regulated by the activation of nuclear factor-erythroid2-related factor 2 (Nrf2). In the normal state of cells, Nrf2 binds to kelch-like ECH-associated protein-1 (Keap1) to form a complex, which exists in the cytoplasm....
These factors contribute to proteinuria, a hallmark of DN, as well as other diabetes complications, including retinopathy and neuropathy. The precise mechanism linking Hhcy and DN remains incompletely elucidated. However, it has been suggested that homocysteine may induce renal injury through various ...
Similarly, T1DM patients suffering from one or more microvascular complications, including neuropathy, display higher levels of endothelial- derived MVs compared to those without diabetic complica- tions[11]. Therefore, the blood levels of MVs are increased in diabetic patients with microvascular ...
Fluoxetine pretreatment can also enhance the effects of MSCs on diabetic neuropathy [27]. Melatonin (MT) is a hormone that was first isolated from the pineal gland in 1959 and widely distributed in the body [28]. MT can promote the transfer of fat-derived exosomes to macrophages, further ...
NEG-mediated crosslinking of structural proteins and the resultant accumulation of AGEs contribute to the long-term complications of diabetes such as cataract, retinopathy, neuropathy, nephropathy, amyloidosis, and Alzheimer’s disease. Histones, which play an important role in chromatin organization and...