ExosomesMesenchymal stromal cellsmicroRNA-146aDiabetic peripheral neuropathy (DPN) is one of the most prevalent chronic complications of diabetes mellitus with no effective treatment. We recently demonstrated that mesenchymal stromal cell (MSC)-derived exosomes (exo-nave) alleviate neurovascular dysfunction ...
In the case of diabetic foot wounds, healing impairments are generally caused by neuropathy, ischemia, and trauma [2]. The conventional management of diabetic foot wounds comprises local surgical debridement, vascular assessment, treatment of active infections, application of wound dressings, and glycemi...
Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments. Lancet Neurol. 2022;21(10):922–36. Article PubMed PubMed Central Google Scholar Fang CH, Wu YL, Zhao JD. Guidelines for clinical diagnosis and treatment of diabetic peripheral neuropathy ...
Guidelines for the diagnosis and outpatient management of diabetic peripheral neuropathy. Diabet Med J Br Diabet Assoc. 1998;15(6):508-514.6. Smith HS, Argoff CE. Pharmacological treatment of diabetic neuropathic pain. Drugs. 2011;71(5):557-589.7. Moxey PW, Gogalniceanu P, Hinchliffe ...
Table 1 Recent Guidelines for Pharmacotherapy of Painful Diabetic Peripheral Neuropathy Pharmacotherapy Treatment Algorithm Given the current international guidelines, physicians should offer a gabapentinoid, TCA, or duloxetine as the first-line treatment as a mono-pharmacotherapy...
Two-year experience with continuous subcutaneous insulin infusion in relation to retinopathy and neuropathy. Diabetes. 1985;34:(suppl 3) 74-794018423Google ScholarCrossref 37. Kroc Collaborative Study Group. Blood glucose control and the evolution of diabetic retinopathy and albuminuria: a preliminary...
chemically induced diabetes by STZ is the most commonly used in vivo model. Although experimental models can be used to predict disease mechanisms or in potential treatment, they may not accurately be translated to human conditions as they do not fully replicate the complexity and heterogeneity of ...
Foot ulcer grade ≥4, inappropriate antibiotics use, overweight, obesity, poor blood glucose control, and neuropathy were found to be predictors of amputation up on multivariable logistic regression analysis. Those diabetic patients who had Grade ≥4 diabetic foot ulcer were1.7 times more likely to ...
Key risk factors for diabetic foot infections encompass neuropathy, peripheral vascular disease, and suboptimal glycemic control, collectively leading to reduced sensory perception, compromised perspiration, foot deformities, and circulatory impairments6,7,8. This intricate interplay can exacerbate skin complica...
Traversi, C. et al. Fractal analysis of fluoroangiographic patterns in anterior ischaemic optic neuropathy and optic neuritis: a pilot study.Clin. Exp. Ophthalmol.36, 323–328 (2008). PubMedGoogle Scholar Simó, R. & Hernández, C. European Consortium for the Early Treatment of Diabetic Retin...