In Brief Diabetic nephropathy, characterized by proteinuria and progressive kidney failure, occurs more frequently when uncontrolled hyperglycemia and hypertension are present. Exaggerated cardiovascular risk is present in these patients, and early detection and treatment are imperative. Successful prevention ...
The kidney is arguably the most important target of microvascular damage in diabetes. A substantial proportion of individuals with diabetes will develop kidney disease owing to their disease and/or other co-morbidity, including hypertension and ageing-related nephron loss. The presence and severity of ...
Prevention and management of chronic kidney disease in type 2 diabetes. Nephrology 15 (Suppl. 1), S162–S194 (2010). PubMed Google Scholar Bello, A. K. et al. Impact of weight change on albuminuria in the general population. Nephrol. Dial. Transplant. 22, 1619–1627 (2007). Article...
The kidney is arguably the most important target of microvascular damage in diabetes. A substantial proportion of individuals with diabetes will develop kidney disease owing to their disease and/or other co-morbidity, including hypertension and ageing-related nephron loss. The presence and severity of...
Diabetic kidney disease (DKD) is the most common cause of chronic kidney disease in the United States. Approximately 30% to 40% of individuals with diabetes mellitus develop DKD, and the presence of DKD significantly elevates the risk for morbidity and mortality. Understanding of DKD has grown ...
Although improvements in DM and hypertension management have reduced the proportion of diabetic individuals who develop chronic kidney disease (CKD) and progress to end-stage renal disease (ESRD), the sheer increase in people developing DM will have a major impact on dialysis and transplant needs. ...
http://www.jnephropharmacology.com Journal of Nephropharmacology Diabetic kidney disease: world wide difference of prevalence and risk factors Osama Gheith1,2*, Nashwa Farouk3,4, Narayanan Nampoory2,4, Medhat A Halim2, Torki Al-Otaibi2 1Urology and Nephrology Center, Man...
.D., senior author on the publication, senior investigator at Joslin Diabetes Center and professor of medicine at Harvard Medical School. This would likely include the delay and prevention of end stage renal disease (ESRD), which is the most serious and advanced stage of diabetic kidney disease...
Kidney sections were fixed by immersion in Carnoy solution followed by 4% buffered formaldehyde and embedded in paraffin. Two-micrometer sections were stained with periodic acid-Schiff and examined by light microscopy. Measurement of the glomerular cross- ...
The traditional strategies for prevention and treatment of DKD, i.e., glycemic control and blood pressure management, have only modest effects on minimizing glomerular filtration rate decline or progression to end-stage kidney disease. While cardiovascular outcome trials of SGLT-2i show a positive ...