3. Risk factors of DKD 3.1. Increased albuminuria Increase excretion of albumin in the urine is a major risk factor for the development and progression of kidney disease in people living with diabetes. It is ch
Diabetic kidney disease (DKD)Diabetic nephropathy (DN)Diabetes mellitusAlbuminuriaDiabetic kidney disease (DKD) is a major cause of morbidity and mortality in patients with diabetes mellitus and the leading cause of end-stage renal disease in the world. The most characteristic marker of DKD is ...
Proinflammatory and profibrotic signaling is a hallmark of diabetic kidney disease (DKD), a serious microvascular complication in patients with diabetes mellitus7,8. The pathomechanisms underlying proinflammatory and profibrotic signaling in DKD involve hemodynamic and metabolic changes as well as DNA damage...
Here, we generate diabetic mice with podocyte-specific overexpression of Ndufs4, an accessory subunit of mitochondrial complex I, as a model investigate the role of ETC integrity in diabetic kidney disease (DKD). We find that conditional male mice with genetic overexpression of Ndufs4 exhibit ...
Diabetic kidney disease (DKD) is the most common cause of chronic kidney disease in the United States. Approximately 30% to 40% of individuals with diabetes mellitus develop DKD, and the presence
Heterogeneity in the Diabetic Kidney Disease (DKD) diagnosis makes its rational therapeutics challenging. Although albuminuria characterizes DKD, reports also indicate its prevalence among non-proteinuric. Recent understanding of disease progression has thus inclined the focus on proximal tubular cell damage ...
The mesangial area and glomerular size in the DKD group were significantly larger than those in the Control group; however, there was no significant difference in those between the DKD and Tx groups. Albuminuria, the ratio of foot process effacement, and thickness of glomerular basement membrane ...
The prevalence of DKD progressively increased with age, and this increment was more evident for low eGFR than for albuminuria. The overall high prevalence of DKD in elderly T2DM patients is likely to be the result of...
Diabetic kidney disease (DKD), the most common cause of kidney failure and end-stage kidney disease worldwide, will develop in almost half of all people with type 2 diabetes. With the incidence of type 2 diabetes continuing to increase, early detection and management of DKD is of great clini...
7 Nearly all patients with low GFR from DKD have preceding albuminuria, and the degree of albuminuria predicts the rate of GFR decline.8, 9, 10, 11 Effective hyperglycemia and hypertension Screening, monitoring, and diagnosing diabetic kidney disease Given the high morbidity and mortality associated...