Several studies have confirmed the protective effects of miR-21 against cardiovascular diseases. miR-21 can improve fibrosis and apoptosis of cardiomyocytes; moreover, the hypoglycemic drug vildagliptin exerts hypoglycemic and cardioprotective effects through the miR-21/SPRY1/ERK/ mammalian target of rapam...
Glucophage,metformin- an antidiabetic drug (trade name Glucophage) prescribed to treat type II diabetes sulfonylurea- antidiabetic consisting of any of several drugs that reduce the level of glucose in the blood; used to treat diabetes mellitus ...
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The US Food and Drug Administration has approved only one topical-growth-factor (GF)-based therapeutic, Becaplermin (0.01% Regranex® gel), with efficacy to promote healing of DFUs [165,166,167]. Although growth factor therapies exhibited promising results in vitro and in small animal models ...
Moreover, co-morbidities like hypertension, obesity, dyslipidemia, and arterial sclerosis have an injurious on the kidney forming complex patterns of nephropathy [2]. DN is characterized by renal functional and structural alterations. Glomerular hyperfiltration, glomerular and renal hypertrophy and ...
These cells show promise in being capable of functional enhancement by our glycomimetic drug; however, future work will focus on animal studies to validate these in vitro data and to identify the mechanism of action and the receptor interaction involved. An understanding of the cytokines released ...
rodents remain the most preferred animal model for the characterisation of the disease and therapeutic drug investigations. These animals are favoured even more than the non-human primates owing to their ability to develop hyperglycaemia one week after a single dose of STZ administration. They have ...
It was also analyzed for its inhibitory effect against the digestive enzymes α-amylase and α-glucosidase, compared with the standard drug acarbose. The formulation showed the presence of major constituents such as steroids, cardiac glycosides, phenols, flavonoids, and saponins. It also had a high...
Considering the reported antioxidant effect of honey [16, 17, 19, 61-63], this might be one of the reasons co-administration of glibenclamide or metformin with honey improved glycemic control better than either hypoglycemic drug in streptozotocin (STZ)-induced diabetic rats [66]....
Because of its short half-life19 and potential neuronal side-effects34, 35, newer, more stable butyrate products with sustained/controlled drug delivery are needed for improving the pharmacokinetic and pharmacodynamic profile of butyrate, and directly or indirectly eliminate its side-effect so that ...