To evaluate the mechanism of insulin resistance in type 1 diabetes mellitus, we measured insulin sensitivity in vivo and insulin action in adipocytes in vitro. The study groups consisted of 18 insulin-treated type 1 diabetic patients and 14 matched normal subjects. In each subject, insulin-mediated...
Metabolic liver disease is highly prevalent in subjects with obesity and involves inflammation, insulin resistance, and fibrosis, leading to cirrhosis. Here, the authors show the IFNγ-IL12 axis in regulating intercellular crosstalk in the liver and playing a major role in the pathogenesis of metabo...
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta cell dysfunction. In high-risk subjects, the earliest detectable a... ME ...
If you have type 1, your body doesn't make enough insulin. Withtype 2 diabetes, your body can make insulin but can't use it well. The cells in your muscles, fat, and liver build up what's called insulin resistance. With type 1 diabetes, you need to use man-made insulin every day ...
CONCLUSIONS/: Offspring birthweight is inversely associated with paternal resistance and in late adulthood, supporting the hypothesis that genetic factors related to action contribute to the association between birthweight and adult and risk. 展开 关键词: Offspring birthweight paternal insulin resistance ...
The impact of insulin resistance on proinsulin secretion in pregnancy: hyperproinsulinemia is not a feature of gestational diabetes OBJECTIVE: Excessive secretion of the insulin precursor proinsulin, as manifested by an increased serum proinsulin-to-insulin ratio, has been associated wi... Rowsey,Ross...
Insulin resistance is localized to skeletal but not heart muscle in type 1 diabetes. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E756-E762, 1993.Nuutila, P, Knuuti, J, Ruotsalainen, U (1993) Insulin resistance is localized to skeletal but not heart muscle in type 1 diabetes. Am...
Impact of blood glucose on cognitive function in insulin resistance: novel insights from ambulatory assessment Article Open access 11 September 2024 BMI, weight change, appetite reduction and cognitive impairment of elderly patients with diabetes Article Open access 18 June 2024 Introduction...
Insulin resistance is one of the most common mechanisms for the growth of diabetes. Insulin resistance is resistance of the bodily tissues to insulin actions. Insulin is basically a hormone released by the pancreas and it is responsible for pushing glucose absorbed from food into cells for providin...
In conclusion, these findings suggest that hUCMSCs-Exos could mitigate the loss of β-cells, improve insulin resistance, and maintain glucose homeostasis on T2DM rats. A strong association exists between increasing age and T2DM, such that its incidence is much greater in the older individuals ...