The present invention permit a method of accurately, conveniently, and rapidly testing the genetic susceptibility of subjects to type-2 by targeting determinative genetic factors of genetic susceptibility to type-2 diabetes.安田 和基春日 雅人門脇 孝...
www.nature.com/scientificreports OPEN Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling received: 30 June 2016 accepted: 26 October 2016 Published: 22 November 2016 in patients with well-controlled type 2 diabetes D. de Gonzalo-Calvo1,2, F....
Type 2 diabetes mellitus (T2DM) is a multifactorial disease resulting from complex interactions between multiple genes and environmental factors1. T2DM is characterized by chronic hyperglycemia, which is known to be caused by insufficient insulin secretion and insulin resistance (IR)2. Oral antidiabetic...
The pathogenesis of type 2 diabetes is not fully understood. We investigated whether circulating levels of preselected proteins were associated with the ou
Although albuminuria has been linked to heart failure in the general population, the relationship between urine albumin-to-creatinine ratio (uACR) and heart failure in type 2 diabetes patients is not well understood. We aimed to investigate the relations
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Lifestyle modifications are considered the most effective means of delaying or preventing the development of type 2 diabetes (T2DM). To contain the growing population of T2DM, it is critical to clarify effective and efficient settings for intervention and modalities for intervention delivery with a wi...
Obesity and type 2 diabetes (T2D) are closely associated with hepatic steatosis (HS), which if untreated can advance to serious liver conditions. Since insulin promotes hepatic lipogenesis, reducing hyperinsulinemia may help in treating HS. E4orf1 is an adenovirus-derived protein that improves gluco...
We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol spec
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