Recent epidemiological data suggest that about 80% of PC patients have impaired glucose tolerance (IGT) or new onset of diabetes. Obesity, smoking, family history, genetic factors, insulin resistance (IR), and chronic pancreatitis are significant risk factors for PC. Several lines of evidences ...
(1993) Insulin resistance and insulin deficiency in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus : errors of metabolism or of ... LC Groop,E Widén,E Ferrannini - 《Diabetologia》 被引量: 548发表: 1993年 Insulin-dependent Diabetes Mellitus, Physical Activity, and Death...
Type 1 women are especially aware of the relationship between hormones and insulin resistance. This is one of the reasons that insulin needs change throughout the month. Pregnancy hormones, in particular, are a beast at creating insulin resistance. All women experience this phenomenon while pregnant...
Both insulin resistance and insulin concentrations correlate with blood pressure in nondiabetic subjects, but there is no consensus on these relations in subjects with non-insulin-dependent diabetes, perhaps because of the use of nonspecific insulin assays and clinic blood pressure measurement. Therefore...
Insulin resistance, impaired early insulin response, and insulin propeptides as predictors of the development of type 2 diabetes: a population-based, 7-yea... 'Insulin resistance, impaired early insulin response, and insulin propeptides as predictors of the development of type 2 diabetes - A ...
islets respond by secreting more insulin to overcome this resistance. This is accomplished largely via an increase in the size and number of beta cells in the pancreas. As type 2 diabetes is a disorder in which islets do not fully adapt to insulin resistance, the implications of these studies...
T2DM is associated with brain insulin resistance, and studies suggest that brain insulin resistance is a feature of AD; however, whether the two conditions are mechanistically linked or represent unrelated occurrences in ageing is unclear Abstract Considerable overlap has been identified in the risk fac...
On the other hand, given the tight homeostatic control of plasma glucose levels in humans, beta-cell dysfunction, relative or absolute, is a sine qua non for the development of diabetes. If insulin deficiency must be present whereas insulin resistance may be present, is this proof that the ...
Prediabetes, which is a combination of excess body fat and insulin resistance, is considered an underlying etiology of metabolic syndrome. Prediabetes manifests as impaired fasting glucose and/or impaired glucose tolerance. Impaired fasting glucose is defined as a fasting blood glucose level of 100 ...
population-based study conducted in Malmö, Sweden, we have previously reported that Middle Eastern immigrants from Iraq represent a high-risk population for type 2 diabetes and that diabetes-related risk factors such as family history of diabetes, obesity and insulin resistance cluster in this popu...