When p-value for the two methods > 0.05, there was no heterogeneity. Horizontal pleiotropy was tested for MR-Egger and MR-PRESSO methods. When p-value for the two methods > 0.05, there was no horizontal pleiotropy. The leave-one-out analysis was performed to determine if any ...
Leave-one-out analysis of the bidirectional effects of type 2 diabetes mellitus (T2DM) with ulcerative colitis (UC) and Crohn's disease (CD). (A) Analysis of T2DM on UC; (B) Analysis of T2DM on CD; (C) Analysis of UC on 2DM; (D) Analysis of CD on 2DM. Full size image Scatte...
One trial, the Da Qing Diabetes Prevention Study comparing a 6-year lifestyle intervention (diet, exercise, or both) with control, found lower all-cause mortality and CVD-related mortality in the combined intervention groups vs control group at 23 and 30 years of follow-up, though not at ...
Once optimized on insulin glargine, subjects were randomized to one of two self-titration algorithm groups adjusting lispro either every day (Q1D) or every 3 days (Q3D) for 24 weeks. The primary outcome was the change in HbA1c from baseline. The primary and secondary objectives were evaluated...
c, d Body weights and blood glucose levels after an oral glucose load (2 g/kg) of cohort one after NogoR treatment. n = 5. d **p = 0.0013; *p = 0.023 by multiple unpaired t-test. AUC **p = 0.0021 by two-tailed unpaired Student’s t-test. e Plasma insulin...
treatment initiation with a single agent and adding a second one only after the loss of plasma glucose control [25]. This approach was supported by large trials (ACCORD, ADVANCE and VADT) that did not find significant advantages for intensive glucose control (e.g. HbA1c below 6.0% or 6.5%...
(e.g., drawing tests, Rorschach) or items evaluating general body image impairment and disturbances (e.g., Fällström & Vegelius,1978; McCraw & Tuma,1977); and one study used two open-ended questions exploring personal experience of body image concerns along with a self-reported body ...
They vary with respect to one time (mainly once-weekly GLP-1 RAs) vs multiple usage and in their ability to deliver one predetermined dose or whether it can be used to choose between several dose settings. For once-weekly exenatide, the microspheres containing the active drug need to be ...
Tirzepatide was one of several single molecule GIPR and GLP-1R agonists developed after the early work in multi-receptor peptides. It is a 39 amino acid linear peptide, similar in size to GIP and GLP-1, which are related hormones both belonging to the secretin family of gut peptides. Th...
Among these patients, the LDL-C treatment targets < 2.5 mmol/L and < 1.8 mmol/L were achieved at the end of follow-up by over two-thirds and one quarter of the patients, respectively. A key finding of our study was the identification of the second-largest patient group with ...