Introduction: Central diabetes insipidus (DI) has been identified as a result of traumatic brain injury. One retrospective study conducted over a 4-year period found a 2.9% incidence of central DI in traumatic brain injury patients. Another study found that 26% of its population dev...
Following 12 hours of overnight water deprivation, morning labs confirmed diabetes insipidus with high serum sodium of 146 mmol/L, high serum osmolality of 306 mOsm/kg, and low urine osmolality of 204 mOsm/Kg. Initiation of oral DDAVP 0.1 mg nightly resulted in a resolution of nocturia and ...
He initially presented to endocrinology with a myelodysplastic syndrome along with idiopathic diabetes insipidus (MRI of the sella unremarkable). He had received multiple blood transfusions for severe anemia (about 18 units in total). He had no prior or family history of pre-diabetes or diabetes;...
Figure 1. Effects of duloxetine treatment on aquaporin-2 (AQP2) protein expression in lithium-induced nephrogenic diabetes insipidus. Immunoblots of AQP2 and pS256-AQP2 are shown; each lane was loaded with a protein sample from a different rat kidney (A). Densitometric analysis revealed that ...