Abstract TP350: The Effect of Type 2 Diabetes on the Transcriptome of Immune Cells in the Bone Marrow in Response to Ischemic Stroke doi:10.1161/str.56.suppl_1.TP350Ischemic strokeDiabetes (Type II)Immune systemInflammation and inflammatory markersCell signalingType 2 diabetes mellitus (T2DM) ...
There are suggestions in the literature that RAAS inhibitors increase ACE2 but again there is a paucity of data to suggest that these have any effect on lung-specific or nasal-specific expression of transmembranal ACE2. Vaduganathan et al. have written a thorough review on the topic of ...
cells. Here, the authors investigate its role by generating animals that lack IL-22RA1 on beta cells and reveal IL22RA1 signalling is critical for insulin biosynthesis and beta-cell health, evidenced by its regulation of MHC II expression and its suppressive effect on inflammation and cellular ...
Immune system dysregulation in people with diabetes mellitus (DM) increases the risk of acquiring severe infection. We compared the clinical characteristics and laboratory parameters of coronavirus disease 2019 (COVID-19) patients with and without DM and estimated the eff...
The recent regulatory approval of the first immunotherapy that targets T cells as a means to delay the autoimmune destruction of pancreatic β-cells highlights the critical role of the immune system in disease pathogenesis and tends to pave the way for other immune-targeted interventions for T1D....
Colchicine exerts a comprehensive inhibitory effect on the immune response, targeting key processes involved in leukocyte function. It inhibits leucocyte chemotaxis, adhesion, and recruitment by disrupting the production of IL-18 and myeloid inhibitory C-type lectin-like receptor (MICL). This disruption...
The IVW method showed that Type 2 diabetes was negatively associated with the risk of aortic dissection (OR 0.763, 95% CI 0.607–0.960), The weighted median, simple mode and weighted mode method showed consistent results. 3-Hydroxybutyrate does not have causal mediation effect on the ...
If Ag derived from apoptotic cells are presented by immature DCs, what are the effects of this phenomenon on the immune system? Repetitive stimulation of PBL with allogeneic immature human DCs has been shown to induce the development of IL-10-producing CD4+ T cells, which were able to ...
Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance. Ann. NY Acad. Sci. 1461, 73–103 (2020). Article CAS PubMed Google Scholar Sims, E. K. & DiMeglio, L. A. Cause or effect? A review of clinical data demonstrating beta cell dysfunction prior to ...
A. et al. The bimodal effect of interleukin 1 on rat pancreatic beta-cells–stimulation followed by inhibition–depends upon dose, duration of exposure, and ambient glucose concentration. Acta Endocrinol.(Copenh) 119, 307–311 (1988). The first study to demonstrate bimodal effect of IL-1 on ...