This association could not be explained by linkage disequilibrium between the Ala45 allele and IDDM7 (D2S152), which is also located on chromosome 2q32. When tested in vitro, the biological activity of Thr45 (117 +/- 36% vs. Ala45) and His197 (90 +/- 28% vs. Pro197) on the ...
Insulin sensitivity is impaired in type 1 diabetes (T1D) and may be enhanced by islet transplantation, an effect best explained by improved metabolic control. While the minimal model index of insulin sensitivity, SI, has been used in studies of T1D, it has not before been evaluated against ...
The YLL rates of diabetes in 1990 and 2010 were 1.68 /1 000 and 2.36 /1000 respectively, and the YLD rates of diabetes in 1990 and 2010 were2.56/1 000 and 3.47/1 000 respectively. The standardized YLL rate and standardized YLD increased by 15.81% and 6.80%,respectively. The male ...
This review also explained the underlying potential mechanisms and elucidated the current state-of-the-art advances in preclinical studies about MSCs-Exos. Mesenchymal stem cells derived exosomes Origin Exosomes, a group of nanoparticles ranging of 30–150 nm in diameter, were first discovered by ...
The cancer-promoting effect of insulins on the liver might be partly explained by portal circulation, which exposes the liver to high levels of insulin in people who have insulin-resistant diabetes23. In addition, insulin use has growth-promoting and mitogenic effects on pancreatic cancer cells, ...
In type 1 diabetes, your body doesn't have enough insulin. Your immune system attacks and destroys cells in your pancreas, where insulin is made, by mistake. In type 2 diabetes, your cells don't respond well to insulin. As a result, your pancreas needs to make more and more insulin to...
Adolescents with type 1 diabetes mellitus may not reach potential peak bone mass, putting them at greater fracture risk. In adults with type 2 diabetes, fracture risk is increased and is not explained by the bone mineral density measured by dual-energy X-ray absorptiometry, still considered the...
The model explained 38% of the variance of glycemic control. The results suggest a possible role of SOC in the psychological and physical wellbeing of people with diabetes. SOC should constitute a focus of further research, particularly studies of possible psychological intervention to enhance SOC ...
The collected data was entered into EPI-manager 4.0.2 and analysis was done using statistical package for social sciences (SPSS) 24. Descriptive data was explained by frequency and percentage. The obtained results were explained by means and standard deviations.Logistic regressionwas used to analyse...
Subclinical inflammation has been implicated in the development of depression, a common comorbidity of type 1 diabetes (T1D) and type 2 diabetes (T2D). This study aimed to characterise the relationships between biomarkers of inflammation and depressive symptoms in T1D and T2D. Biomarkers of inflamma...