DHHC是一种酰基转移酶，在人体中有着非常重要的作用。这种酵素可以将蛋白质上的一个或多个亮氨酸残基酰化，从而赋予蛋白质疏水性质，使得其在膜上的定位或催化功能得以实现。DHHC的全称为Asp-His-His-Cys型酰基转移酶，其中Asp和His是催化过程中所需的基团，而Cys则是催化所需的催化基。DHHC酶在神经...
这一类蛋白的结构具有共同的特征,都含有特征性的锌指样(Zinc finger)-DHHC (Aspartate-histidine-histidine-cysteine)-CRD (Cysteine rich domain)结构域,因此这类蛋白又被称为DHHC蛋白家族,其家族的大多数成员具有棕榈酰转移酶活性。 近期一组研究人员破解了首个DHHC酶的三维结构,并鉴定出了这个蛋白的一个重要结构成...
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2023年3月10日,DiamondHead Holdings Corp.(NASDAQ:DHHC)今天在一份8-K中宣布,已经重新安排其与住宅建筑公司Great Southern Homes Inc.完成交易的特别会议。 公司最初计划在3月14日举行完成投票,但现将其推迟到3月23日上午10:00(东部时间)以便更多时间准备收盘物流。赎回期限也将从3月10日延长至3月21日。 SPAC...
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These findings identify reduction of DHHC5-mediated beclin 1 S-palmitoylation as an underlying mechanism by which aging induces autophagy decline. This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+,...
基于转录组的油茶DHHC型锌指蛋白基因家族的鉴定及分析 徐嘉娟,朱亚艳,李芳,许杰,王港* (贵州省林业科学研究院,贵州 贵阳 550005) 蛋白质的翻译后修饰(posttranslational modification)与其稳定性和生理功能的正确行使息息相关[1-3]。棕榈酰...
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Background: This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase This protein specifically palmitoylates HRAS and NRAS Mutati...