DHFR-TS amplification and resistance to 5-fluorouracil.JeanFrançois RittFrédéric RaymondPhilippe LeprohonDanielle LégaréJacques CorbeilMarc Ouellette
刚地弓形虫：遗传筛选与DHFR—TS相连的融合蛋白 维普资讯 http://www.cqvip.com
必应词典为您提供DHFR-TS的释义,网络释义: 酶缺乏;功能蛋白;
Plasmodium falciparum dihydrofolate reductase–thymidylate synthase (PfDHFR-TS) is an important target of antimalarial drugs. The efficacy of this class of DHFR-inhibitor drugs is now compromised because of mutations that prevent drug binding yet retain
Pemetrexed(LY-231514, LY231514),又称培美曲塞、培美曲塞酸、培美曲塞二酸或培美曲赛酸,是一种新型抗叶酸和抗代谢药物,通过破坏细胞内叶酸依赖性的正常代谢过程来抑制细胞生长。Pemetrexed作用于DHFR、TS和GARFT,Ki分别为7.2 nM、1.3 nM和65 nM。培美曲塞常与顺铂联合用于局部晚期或者转移性非鳞状细胞型非小细胞肺...
Based on the DHFR-TS gene sequence, siRNA was designed. The siRNAs were transfected into the parasites by electroporation. Total RNA was extracted using RNX-Plus kit. The viability of parasite was assessed by methylthiazole tetrazolium (MTT). The survival time of mice challenged with siRNA-...
Keywords:DHFR-TS;TR;Trypanosomacruzi;Polymorphism;Evolution 1.Introduction Enzymesthatareessentialtothemetabolismof parasiticprotozoaareattractivetargetsforantiparasite chemotherapy.Drugsthatblocktheactivityofthose enzymescaninhibittheparasite’sgrowthandtherefore representviablealternativesorcomplementstothe developmentofvac...
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TS, DHFR and GARFT expression in non-squamous cell carcinoma of NSCLC and malignant pleural mesothelioma patients treated with pemetrexed. BACKGROUND: Recently, pemetrexed (PEM), a new generation antifolate, has been used for the treatment of patients with advanced non-squamous cell carcinoma ......
AntifolateAutophagyDHFRDNA/RNA Synthesis ¥ 180 现货 规格 数量 Piritrexim 吡曲克辛, BW 301U T2464472732-56-0In house Piritrexim (BW 301U) 是一种可口服的脂溶性二氢叶酸还原酶抑制剂,具有肺毒性,用于研究尿路上皮癌和转移性乳腺癌。 DHFR