2.Johnson MD, Bebb RA, Sirrs SM. Uses of DHEA in aging and other disease states. Ageing Res Rev. 2002 Feb;1(1):29-41. 3.Baulieu EE, Thomas G, Legrain S, et al. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution ...
不过,不像其他的类固醇贺尔蒙,人体体内的DHEA分泌量在25到30岁间达到高峰,之后就随着年龄增长,逐渐下降。到70岁的时候,只剩下25岁时的20%而已。 血液中的DHEA循环量,包含自由态的DHEA以及DHEA硫酸盐(DHEA sulfate,简称DHEA-S),DHEA-S是DHEA与硫酸分子辖合在一起的型式。不过,研究人员一般都将这两种形式的DHEA...
脱氢表雄酮(dehydroepiandrosterone,DHEA)是肾上腺及卵巢合成雌二醇及睾酮过程中的中间产物,在肾上腺硫酸化酶的作用下可生成硫酸脱氢表雄酮(dehydroepiandroster0nesulfate,DHEAS),两者是人体内含量最多的类固醇激素。 育龄期女性体内DHEA水平随年龄增长明显下降。体内绝大多数DHEA源自肾上...
Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue. Proc Natl Acad Sci U S A 2000, 97(8): 4279-4284. [14] Weiss EP, Villareal DT, Fontana L, Han DH, Holloszy JO. Dehydroepiandrosterone (DHEA) replacement decreases insulin...
Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Proc Natl Acad Sci U S A. 1998; 95 :1852–1857.Kimonides VG, Khatibi NH, Svendsen CN, Sofroniew MV, Herbert J. Dehydroepiandrosterone (DHEA) and DHEA-...
Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. J Clin Endocrinol Metab . 1998 Jun;83(6):2012-7...
(131)Straub RH, Konecna L, et al. Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. J Clin Endoc...
DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear. In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are synthesized in the brain, further suggesting a role of these hormones in brain function and development. Despite intensifying...
功能补剂只是在一定程度上帮助改善,但对于难孕问题,我们还是要从整体出发,找到原因,做全面干预,才能有最佳效果。 [3] 田洁,姜国辉,脱氢表雄酮(DHEA)对卵巢储备功能低下患者卵巢功能的改善效果研究[J]…
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