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, 1990). As is true of PEG conjugates with proteins, dextran modification of macromolecules provides increased circulatory half-life in vivo, decreased immunogenicity, and a heat and protease protective effect when coupled at sufficient density (Mumtaz and Bachhawat, 1991). The following sections ...
The three conjugates were found to be stable in HCl 0.1N, phosphate buffer solutions pH 6.8 and 7.4 incubated at 37 degrees C within 6h and the rate constants for degradation of conjugates to budesonide and budesonide hemisuccinate were less than 0.006h(-1). Less than 10% of the drug was...
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pH-responsive nanoparticles for drug delivery. Mol Pharm. 2010;7(6):1913–20. Article Google Scholar Chau Y, Dang NM, Tan FE, Langer R. Investigation of targeting mechanism of new dextran-peptide-methotrexate conjugates using biodistribution study in matrix-metalloproteinase-overexpressing tumor ...
described. The dextran-based polymer tissue adhesive is particularly useful in medical applications where low swell and slow degradation are needed, for example sealing the dura, ophthalmic procedures, tissue repair, antiadhesive applications, drug delivery, and as a plug to seal a fistula or the ...
Dextran is degraded enzymatically by dextranase, which is present in the human body in the colon, spleen, kidneys and lungs. This enzymatic degradation can be regarded important in the application of dextran and dextran conjugates.doi:10.1002/9781119126218.ch18Rong Wang...
Dextran is degraded enzymatically by dextranase, which is present in the human body in the colon, spleen, kidneys and lungs. This enzymatic degradation can be regarded important in the application of dextran and dextran conjugates.doi:10.1002/9781119126218.ch18Wang, Rong...
targeted deliverydextransconjugatesTargeted polymer-drug conjugates or nanoparticles decrease toxicity of chemotherapeutic agents by localizing it where it is required. We have synthesized conjugates that target galactose binding receptors on hepatocytes. In vitro studies show lower toxicity of doxorubicin when...