The other work, recently published by the authors of the present investigation, evaluated DEX clinical effects within the intranaesthetic period and the recovery phase when administered as CRI or following repeated subcutaneous (SC) injections [19]. On the other hand, DEX pharmacokinetic profile ...
Fertility in male or female rats was not affected after daily subcutaneous injections of dexmedetomidine at doses up to 54 mcg/kg (1.5 times the MRHD of 360 mcg/day on a mg/m² basis) administered from 10 weeks prior to mating in males, and 3 weeks prior to mating and during mating...