DExD/H-box helicases play critical roles in multiple cellular processes, including transcription, cellular RNA metabolism, translation, and infections. Several seminal studies over the past decades have delineated the distinct functions of DExD/H-box helicases in regulating antiviral innate immune ...
Ribosome synthesis requires a multitude of cofactors, among them DExD/H-box RNA helicases. Bacterial RNA helicases involved in ribosome assembly are not essential, while eukaryotes strictly require multiple DExD/H-box proteins that are involved in the much more complex ribosome biogenesis pathway. ...
DDX58 Antibody is a Rabbit Polyclonal antibody against DDX58. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This ge...
DExH box RNA helicases, which require the help of other proteins and ATP hydrolysis, act as molecular motors that rearrange inter- or intramolecular RNA secondary structures or that dissolve RNA- protein complexes. Only a few RNA helicases have been analyzed in Arabidopsis. LOW EXPRESSION OF OSM...
DExD/H-box RNA helicases play important roles in mediating structural changes of the spliceosome by unwinding of RNA duplexes or disrupting RNA-protein interactions. DExD/H-box proteins are also implicated in the fidelity control of the splicing process at various steps. This review summarizes ...
DExD/H-box proteins are a diverse class of proteins that are implicated in RNA and RNP remodeling. They have sequence homology to DNA helicases and share conserved ATPase domains, suggesting that they use the energy of ATP binding and hydrolysis to mediate conformational rearrangements in RNAs. ...
Outline Highlights Abstract Abbreviations Keywords 1. Introduction 2. RNA helicases in innate anti-viral immunity 3. RNA helicases in viral replication 4. Concluding remarks Acknowledgements ReferencesShow full outline Cited by (148) Figures (1)...
DExD/H Box RNA helicases. Mol. Cell 8, 251-262.Tanner, N.K., and Linder, P. (2001). DExD/H box RNA helicases. from generic motors to specific dissociation functions. Mol. Cell 8, 251-262.Tanner NK, Linder P. DExD/H box RNA helicases:...
Besides the catalytic core, HrpB possesses three accessory domains, conserved in all DExH-box helicases, plus a unique C-terminal extension (CTE). The function of these auxiliary domains remains unknown. Here, we characterize genetically and biochemically Pseudomonas aeruginosa HrpB homolog. We ...
Hepatocyte ferroptosis plays a critical role in liver I/R injury, however, it remains unclear whether this process is controlled or regulated by members of the DEAD/DExH-box helicase (DDX/DHX) family. Methods: The expression of DDX/DHX family members during liver I/R injury was screened ...