Individuals in the non-spectrum profile show non-spectrum symptom severity in both the SA and RRB domains. Individuals in the RRB and SA profiles show ASD symptoms on the autism spectrum level in the SA and RRB domains, respectively, while scoring within the normal range in the other domain....
Manual scoring was conducted, and the resulting data was plotted and analyzed. All experiments were conducted in 3 independent biological trials. To compare the survival rates a two-sided Kaplan-Meier method was used. The statistical significance was calculated using the Log-rank (Mantel-Cox) test...
From worms to humans, the nervous system undergoes extensive transcriptional and functional transformation upon sexual maturation18,21,54. We thus searched specifically for neuronal gene families that display sexually dimorphic expression in our dataset. We examined transcription factor families55, including ...
social communication difficulties To provide an absolute measure of shared genetic influences between traits and clinically recognised conditions, we assessed the phenotypic variance in rank-transformed social communica- tion difficulties due to risk-increasing alleles using polygenic scoring43,44 (Table 1)...
Individuals scoring high on this personality dimension can be characterized as worried, emotionally unstable, overly reactive or nervous [5]. Particularly, the association between high neuroticism and internalizing disorders like depression [6],[7] or anxiety disorders [8],[9] is well established. ...
The authors recommend that examiners be familiar with the manual and have some experience administering tests to children. Roughly 45–90 min are required to administer and score the PEP-R (Schopler et al., 1990). A revision of the PEP-R, the Psychoeducational Profile-Third Edition (PEP-3;...
Gene signature scoring The Seurat “AddModuleScore” function was used to calculate gene signatures. The self-renewal score used 13 genes (CSF1R, MYC, MYB, PCNA, TOP2A, MKI67, CDK1, MCM6, CCND1, CCND2, CCND3, JUN, FOS) associated with the literature (Gentek et al., 2014). The ...
Thus, each autistic individual has their own unique profile of strengths and challenges, which may influence not only a person’s experience of well-being, but also their definition of what constitutes their specific well-being. Furthermore, many autistic people are reported to have co-occurring...
andSU/low family risks. Most children stayed in the same profile (64.2%), while the rest transitioned between profiles. Children exposed to caregiver SU and family adversity had lower positive outcomes in adolescence. Stable membership in theSU/family risksprofile had significant maladaptive consequenc...
This finding suggests that children with CIs may display a similar profile to that of children with DLD. However, this result may be related to the characteristics of this specific group of children with CIs. In fact, the group reported poor comprehension abilities on average (that is, a low...