Congenital abnormalities of the kidney and urinary tract (CAKUT) are the cause of 30–50 % of end-stage renal disease in young children [306]. CAKUT are represented by a heterogeneous group of renal, ureter, and bladder malformations across a wide range of clinical severity (Table 1.1). Th...
The kidney is a favorite subject of developmental biologists. In the past decade, we have gained a great deal of knowledge about the regulation of kidney development. This review describes the organization of the kidney, the molecules involved in the regulation of kidney development, and a unique...
The development of the kidney in fetal rats was investigated morphometrically and ultrastructurally. Both the length and volume of the proximal tubule increased with age. The total volume of functional glomeruli increased markedly from fetal day 20 onward. The ratio of total glomerular volume to tot...
These results suggest that JF enables the accurate evaluation of organ doses due to diverse exposures to Japanese adult females. Photon-specific absorbed fractions (SAFs) for liver or stomach as target organs and for kidney as a source organ were calculated using JF and compared with those of ...
During metanephric kidney development, renin is expressed in the walls of larger intrarenal arteries, but is restricted to the terminal part of the preglomerular arterioles in the adult kidney. Our study describes the three-dimensional development of renin expression in mouse kidneys during fetal and...
The process of sexual differentiation is central for reproduction of almost all metazoan and therefore for maintenance of practically all multicellular organisms. In sex development we can distinguish two different processes: First, sex determination is
Histone Deacetylases Take Center Stage on Regulation of Podocyte Function Background: Podocytes (highly specialized and terminally differentiated epithelial cells) are integral components of the glomerular filtration barrier that... M Liu,Z Qiao,Y Zhang,... - 《Kidney Diseases》 被引量: 0发表: ...
Appreciating the mechanisms responsible for normal retinal development is critical to understanding disease processes affecting the pediatric retina. Remarkably, the retina develops over a relatively long period of time beginning from the early gestation
The mechanisms underlying kidney development in mice and humans is an area of intense study. Insights into kidney organogenesis have the potential to guide our understanding of the origin of congenital anomalies and enable the assembly of genetic diagnos
In the past few decades, the modulation of PPIs has been recognized as one of the most challenging drug discovery tasks. In recent years, some PPIs modulators have entered clinical studies, some of which been approved for marketing, indicating that the modulators targeting PPIs have broad ...