ai want anew pair of sneakrs 我重新想要对sneakrs[translate] a无义 Does not have righteousness[translate] a癌细胞的生存和发展离不开蛋白质的合成,然而,癌细胞在合成蛋白质时,则必须从健康细胞中夺取门冬酰胺,可是,与门冬酰胺共生的门冬酰胺酶却能控制癌细胞的生长,这是它无法
Cancer metastasisTherapy resistanceThe term "cancer stem cells" (CSCs) refers to cancer cells that exhibit traits parallel to normal stem cells, namely the potential to give rise to every type of cell identified in a tumor microenvironment. It has been found that CSCs usually develops from other...
components of the extracellular matrix (ECM), heterogeneous cells populations including fibroblasts, cancer stem cells (CSCs) and immune cells [2]. Solid tumors are commonly affected
Diverse endogenous features of cancer cells modulate BCL-2 family protein dependencies, as do imposed features such as the cellular response todrug treatments. The parallel development of selective, potent BH3 mimetic drugs, combined with our evolving understanding of the landscape of BCL-2 family vu...
School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany Moritz Thomas Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany Lisa Rohrbacher & Marion Subklewe Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Munich, German Re...
Upstream mediators of EMT such as ZEB1/2, TGF-β, microRNAs, and so on are involved in regulating response of cancer cells to PTX and DTX. Tumor-suppressing factors inhibit EMT to promote PTX and DTX sensitivity of cancer cells. Furthermore, three different strategies including using anti-...
W. et al. Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferation. Cancer Res. 63, 6237–6243 (2003). CAS PubMed Google ...
focus of research has now shifted from survivin expression in the overall heterogeneous tumor cell populations to survivin expression in cancer stem cells as these cells have proved to be the major drivers of tumors. Therefore, in this review we have analyzed the expression of survivin in normal ...
Lysosomes can move to the plasma membrane, release various enzymes, such as cathepsin, to the outside of the cell and degrade collagen fibers and integrins to “remodel” the ECM and promote the metastasis of cancer cells [40, 43, 44]. (5) In cancer cells, MVBs can move to the plus ...
MUC1 functions primarily in the formation of a physical barrier to lubricate and protect normal epithelial tissues and mediate signal transduction [2]. However, aberrant expression of MUC1 occurs in cancer cells, including those of oesophageal cancer, gastric cancer, breast cancer, ovarian cancer, ...