Therefore, targeting of the host fac- tors required for viral replication is currently considered a promising strategy for drug development, one that overcomes the drug resistance problem due to the low mutational rate within eukaryotic cells28,29. Furthermore, these host-targeting agents can ...
Regulatory network construction and analysis is a complex problem with no one easy solution. However, knowing both the starting point (the mutant miR-96) and the end points (the misregulated transcripts) means a set of hypothetical pathways can be drawn up, examined for consistency and tested ...
Maternal smoking is a risk factor for pediatric lung disease, including asthma. Animal models suggest that maternal smoking causes defective alveolarization in the offspring. Retinoic acid signaling modulates both lung development and postnatal immune function. Thus, abnormalities in this pathway could med...
8 Data availability statement We have the data relating to the study that can be provided upon a request to the corresponding author at any point of time.Notes The “Hindu rate of growth” in the Indian literature refers to the annual growth rate of the Indian economy prior to the economic...
reasoning and problem solving, and social cognition [12,13,14]. Large studies indicate that cognitive performance in patients with schizophrenia is one to two standard deviations lower than in age-matched control subjects [15]. Mostly normal cognitive profiles have been reported only in a small pr...
Sigma function 𝑠𝑖𝑔(𝑣)sigv aims to narrow the numeric values into confined space [0, 1] in order to improve the performance of the algorithm [40]. Figure 1 shows a systematic diagram for working of the binary optimization particle swarm. The algorithm used here operates differently...
(SBA-EPD). In this study, a collagen graft shaped like a sponge through SBA-EPD was used to treat acute and chronic TM perforations in a chinchilla model. A total of 24 ears from 12 adult male chinchillas were used in the study. They were organized into four groups. The first two ...
A traditional logistic regression was also performed to be compared with the machine learning models. Results: Random Forest model showed the best performance, and the top five predictive features included age, preoperative creatinine values, time of aortic cross-clamping, body surface area, and ...
The decision maker thus faces a paradox by which the choice of an MCDA method becomes a decision problem in itself [37,38]. It should also not be forgotten that MCDA methods include subjective information provided by the decision maker, such that a change of decision maker can lead to a ...
Regarding these notes altogether and the problem statement, we construct a multi-period mixed integer nonlinear programming (MINLP) model as follows. 4.1. Objective Function The objective function in the developed programming model seeks to maximize the total average profit per hour, which is defined...