The fast and accurate determination of molecular properties is highly desirable for many facets of chemical research, particularly in drug discovery where pre-clinical assays play an important role in paring dow
This sys- strength of hydrogen bonds that disfavors significant octahedral tilting in this system, since these are formed on both sides of the molecule232, rendering the system pseudocubic. Nevertheless, multiple experimental results reveal that the ground state of the system involves complex disorder...
However, the quanti- tative description of DSC which can deconvolute the super- position of the underlying thermal phenomena is missed. In DSC trace of heat flow versus temperature, the slope is representative of the heat capacity of the samples (Eq. 1) (if the trace has been normalized ...
Small polar molecules such as ammonia exhibit a relatively high permeability coefficient on the order of 10–1 cm/s, whereas urea, a slightly larger polar molecule, is closer to 10–6 cm/s (Walter and Gutknecht 1986; Yang and Hinner 2015). Transcellular permeability is nearly non-existent ...
The charge argument is also hard to reconcile with tRNAs carrying ∼70 negatively charged groups per molecule and yet being exported by exportins and not by self-translocation through the NPC barrier. To address this issue, we generated a charge-series by introducing isosteric D↔N and E...
The collagen molecule is composed of three polypeptide chains that wind around each other to form a 1.5-nm-thick triple helix ∼300-nm long. Each chain’s primary amino acid sequence includes both polar and apolar residues grouped in alternating hydrophilic and hydrophobic patches (9). Collagen...
(the difference between intravascular blood pressure,plum, and interstitial fluid pressure,pins) and vessel diameter,dv19. However, transport of glucose, a hydrophilic polar molecule, is more complex59. In addition to transvascular pressure and vessel diameter, efflux from blood and influx to the ...
(yellow). To obtain an overall understanding of the spatial cluster distribution on the receptor molecule, we plotted cluster colors on the FZD5snake plot (Fig.7c) as well as a three-dimensional FZD5model (Fig.7d). Interestingly, the residues within each cluster are spread over the entire ...
Relative permittivity (the real part of the complex permittivity) measures the degree to which a medium resists the flow of electric charge. Water is a polar molecule with a permanent dipole moment and will rotate to align with an applied electric field. This is taken advantage of in the freq...
While very large compared with the structures of an atom or molecule, the magnetic domains of ferromagnetic materials are for the most part invisible to the unaided eye. On polished surfaces they do sometimes become visible with the help of a simple optical microscope, and domain structures can ...