Once a primary solid tumor exceeds a threshold volume (~1 mm)30, its central cells become starved because the outer surrounding cells deplete the nutrients; in response, the central cells secrete a variety of morphogenic and chemotactic growth factors31such as vascular endothelial growth factor (...
Embodiments of the present disclosure relate to determining changes in a vasculature by analyzing changes in one or more attributes of a plethysmographic signal. According to certain embodiments, an a
Calculations using this so-called large deviation theory show that the Milner–McLeish theory without CR overestimates the FP time by a factor of 10 or more. For examining the assumptions made in different theoretical models and validating their predictions, molecular dynamics (MD) simulations based...