Derive Ka and pKa, starting from the chemical equation for the dissociation of a strong acid (HA) in water. What quantity (moles) of NaOH must be added to 1.0 L of 2.0 M HC2H3O2 to produce a solution buffered at each pH? A) pH 5 pKa B) pH 5 4.00 C) pH 5 5.00 ...
The pKA for clonidine ranged from 8.95 in the mouse, 7.8 in rat and 8.3 in guinea pig. The propranolol pKB was 8.87 in mouse and 8.91 in rat atria, reading very similarly to those values from 尾-adrenoceptor agonist assays under equilibrium conditions. In mesenteric resistance arteries mounted...
All recombinant tropomyosin isoforms were purified as described previously (Hitchcock-DeGregori and Heald, 1987, Hammell and Hitchcock-DeGregori, 1996, Moraczewska et al., 1999). The N-termini are unacetylated. Acetylated striated muscle α-tropomyosin was purified from the isoelectric precipitate ...
Activation of the cAMP/PKA/DARPP-32 signaling pathway is required for morphine psychomotor stimulation but not for morphine reward. Neuropsychopharmacology. 2007;32:1995–2003. CAS PubMed Google Scholar Marinelli M, Piazza PV. Interaction between glucocorticoid hormones, stress and psychostimulant ...
We analysed the ligand-based activation mechanism of the prostate-specific G-protein coupled receptor (PSGR), which is an olfactory receptor that mediates cellular growth in prostate cancer cells. Furthermore, it is an olfactory receptor with a known che
like fruit flies, rats, and nematodes that caloric or dietary restriction extends the life span by probably downregulating insulin und insulin-like signaling, the amino signaling target of rapamycin (TOR)-S6 kinase pathway, and the glucose signaling Ras-protein kinase A (PKA) pathway [72,73,74...
like fruit flies, rats, and nematodes that caloric or dietary restriction extends the life span by probably downregulating insulin und insulin-like signaling, the amino signaling target of rapamycin (TOR)-S6 kinase pathway, and the glucose signaling Ras-protein kinase A (PKA) pathway [72,73,74...
P Biliński,L Kapkaskrzypczak,P Jabłoński - 《Annals of Agricultural & Environmental Medicine Aaem》 被引量: 30发表: 2012年 Drug Abuse Perception and Associated Variables among Secondary School Students in Duhok City Background: Nowadays, illicit drug abuse is becoming a serious public health pr...
(Ka = 5.62 x 10-10) Determine the molarity of an aqueous solution of ammonia that has a pH of 11.15. (Kb = 1.8 x 10-5) Determine the molarity of an aqueous solution of ammonia that has a pH of 11.50. (Kb = 1.8 x 10-5) Determine the p...
However, the functional efficacy parameter τ is inter- dependent on two other parameters of OM; agonist's KA and the highest response that could be evoked in the system by any stimulus (EMAX). Thus, fitting of OM to functional response data is a tricky process. In this work we analyse ...