Acidity constantWe applied the principle of feedback-based flow ratiometry, originally developed for continuous titrations, to the determination of acid dissociation constants ( K a). The titrant (NaOH) flow rate F B was varied in response to a control voltage V c from a controller, while ...
The dissociation cons... RN Roy,JJ Gibbons,CHT Jr - 《Analytica Chimica Acta》 被引量: 0发表: 1978年 Acid–base equilibria of co-ordinated ligands. Part 1. The effect of basicity of co-ordinated nitrogen donors upon the acidity of chelating 8-aminoquinoline in some dicationic platinum(II)...
polyproticweakacid;pHvalue;Gauss.Newtonmethod ArticleID:1006.4982(2003)02.0098.03 Ionizationconstantsofpolyproticweakacidsare Fromthemassbalance ,Eq.(2)canbegotten: basicthermodynamicsdata.Undermanycircumstances , CHA-[HA]+[H A一]+[H州A一]+ measurementsofionizationconstantsofpolyprotic weak acidsare...
The data set thus generated was fitted to the equilibrium equation and the best fit values for the dissociation constant, K_d and the molar difference absorption coefficient at the maximum wavelength, Aemax, were determined. The method was successfully applied to ribonuclease F1-guanosine 2'-...
The pharmacokinetic properties of these weak base compounds are significantly influenced by their acid-base dissociation constant, pK a. The knowledge of this value is crucial for new drug development. This paper is aimed at developing a methodology that utilizes pH-dependent 1H NMR spectroscopy for...
weak acids that dissociate into a hydronium ion (H 3 O + ) and a conjugate base anion (In – ). This dissociation can be represented through the following equation and equilibrium expression: + - + - 3 2 3 weakacid conjugatebase hydronium indicator indicator ion [H O ][In ] HIn (aq...
Determination of the dissociation constant and analyzing for the pH curve for the titration of a weak monobasic acid and a strong base : Utilization for ch... This work is focused on the simultaneous determination of different nucleosides (lamivudine, abacavir, zidovudine) and non-nucleoside (nevir...
The mechanism for an acid-base disturbance can be determined with the simplified strong ion approach, which requires accurate values for the total concentration of plasma nonvolatile buffers (A(tot)) and the effective dissociation constant for plasma weak acids (K(a)). The aims of this study ...
The pH calculated from DIC, P CO 2, and the first dissociation constant of carbonic acid ( K 1) data was consistently higher than that directly measured with a pH electrode. Similarly, calculation of P CO 2 of surface waters from pH, DIC, and K 1 data gave values up to twice that ...
Interestingly, only 3/8 were found to be weak or non-binders (IC50 > 500 nM), possibly due to averaging two overlapping motifs in our data. Notably, the predictions of legacy algorithms showed no correlation with measured IC50 (Fig. 5f). However, many of these deficiencies were ...