DNA can determine where and when genes are expressed, but the full set of sequence determinants that control gene expression is unknown. Here, we measured the transcriptional activity of DNA sequences that represent an ~100 times larger sequence space than the human genome using massively parallel...
The "principle of sensitive dependence," while an admirable aspiration, proves a counsel of perfection beyond reach of the historian when applied to those same events. As to historical explanations in terms of structural, impersonal determinants, these remain ascendant, to the neglect of human ...
Evidence of direct action of testosterone in adipose tissue also comes from studies that have demonstrated the presence of testosterone receptors (85) and testosterone binding (86) in both human and rodent adipocytes. Consistent with these data, long-term testosterone deficiency has been shown to ...
actor-network, motivation, and human–environment interaction hypothesis. Applying survey data from users of China’s three leading E-commerce platforms (Taobao, Jingdong, and Pinduoduo), we adopt structural equation modeling, machine learning technique, and ...
One of the most significant legal acts concerning the sale and management of insurance risk was issued on January 20, 2016, based on Directive (EU) 2016/97
Integrity; upholding our obligations in spite of personal inopportuneness. Concept of Ethics in Indian tradition:In Indian culture, the phrase morality and ethics is 'dharma'. Dharma originates from "dhr", which means to hold together. And thus the function of dharma is to hold the human ...
activity levels (e.g., NFAT and YY), activity increased linearly rather than synergistically as a function of the number of binding sites (Extended Data Fig.1e). The simplest model consistent with these observations is that human enhancer activation requires overcoming a repressive activity, after...
Lim SH, Kim DJ, Hur Y, Park K (2019) An empirical study of the impacts of perceived security and knowledge on continuous intention to use mobile fintech payment services. Int J Human-Comput Interact 35(10):886–898.https://doi.org/10.1080/10447318.2018.1507132 ...
These results suggest that sequence properties of microsatellites have a significant impact in determining the features of human microsatellite variability. Background Microsatellite loci consist of short tandem repeats (STR) that vary in length between individuals and that generally have many distinct allel...
Viral proteins, in particular glycosylated retrovirus envelope proteins, are potent inducers of inflammation with ensuing cell damage and death [2]. Approximately 8% of the human genome is comprised of retrovirus-like sequences (retroelements) [3], [4], represented chiefly by human endogenous ...