Detergent-resistant microdomains offer no refuge for proteins phosphorylated by the IgE receptor. J Biol Chem. 2000;275(45):34976-82.M. Peirce, H. Metzger, Detergent-resistant microdomains offer no refuge for proteins phosphorylated by the IgE receptor, J. Biol. Chem. 275 (2000) 34976 - ...
These findings suggest that the MAM, bearing cholesterol and ceramide-enriched microdomains at the ER, may use the microdomains to anchor Sig-1Rs to the location; thus, it serves to stage Sig-1R at ER-mitochondria junctions.Access through your organization Check access to the full text by ...
Studies in cell lines have shown that -secretase is partially localized to lipid rafts, which are detergent-resistant membrane microdomains enriched in cholesterol and sphingolipids. Here, we studied -secretase in detergent-resistant membranes (DRMs) prepared from human brain. DRMs prepared in the ...
Cholesterol-rich membrane microdomains known as lipid rafts have been implicated in diverse physiologic processes including lipid transport and signal transduction. Lipid rafts were originally defined as detergent-resistant membranes (DRMs) due to their relative insolubility in cold non-ionic detergents. Re...
these specialized microdomains in lipid signaling [11–16]. Lipid messengers are generated by the concerted action of phospholipases and lipid kinases on membrane phospholipids. Phosphatidylcholine (PC), the most abundant glycerophospholipid in the membrane, plays a key role in cellular signaling since...
Corsetto PA, Cremona A, Montorfano G, Jovenitti IE, Orsini F, Arosio P, Rizzo AM: Chemical-physical changes in cell membrane microdomains of breast cancer cells after omega-3 PUFA incorporation. Cell Biochem Biophys. 2012, 64: 45-59. 10.1007/s12013-012-9365-y Article CAS PubMed Google ...
There is a general agreement that DHA actively modifies the DRMs organization, producing DRMs disassembly and cholesterol displacement, inducing lateral phase separation into PUFA-rich/sterol-poor microdomains and impairing the activity of many DRM-associated proteins[34,36]. Pgp is one of these protei...
M. (2010) Detergent-resistant microdomains mediate activation of host cell signal- ing in response to attaching-effacing bacteria. Lab. Invest. 90, 266 -281G. Shen-Tu, D.B. Schauer, N.L. Jones, P.M. Sherman, Detergent- resistant microdomains mediate activation of host cell signaling in ...
Here, for the first time we have shown that a single receptor, CD40, by virtue of its re-localization within cholesterol-rich detergent-resistant membrane microdomains (DRMs), can assemble a signalosome able to induce pro-inflammatory mediators and immunity to L. major, while the same receptor ...
Detergent-resistant microdomains mediate activation of host cell signaling in response to attaching- effacing bacteria. Lab Invest. 90:266-81.Shen-Tu, G., Schauer, D. B., Jones, N. L., and Sherman, P. M. (2010) Detergent-resistant microdomains mediate activation of host cell signal- ing...