Desmin exhibits the usual structural characteristics of an IF protein with a central rod portion made up of α-helical domains and the head and tail regions consisting of poorly conserved, relatively disordered peptide sequences. These characteristics, when the monomers associate to form the mature ...
desmosomal cadherins undergo a locking mechanism that creates a periodic arrangement, trapping Ca2+, and resulting in strong extracellular Ca2+-independent adhesive properties, or the desmosomal cadherins form a series of densely tangled knots with no regular structure. A crystal structure has not ye...
Monophyly of the family Desmoscolecidae (Nematoda, Demoscolecida) and Its Phylogenetic position inferred from 18S rDNA sequences To infer the monophyletic origin and phylogenetic relationships of the order Desmoscolecida, a unique and puzzling group of mainly free-living marine nemat... UW Hwang,...
Corneodesmosin, also known as CDSN and the S gene product, is a highly polymorphic secreted glycoprotein that plays an important structural role in the skin (1). It is expressed by differentiated keratinocytes in the corneal layer of the skin and is a major component of corneodesmosomes (2 ...
Up to 2.8 kilobases of the upstream genomic sequences were sequenced and found to contain several putative cis-regulatory elements. The promoter region was GC-rich and TATA-less, similar to previously characterized mammalian cadherin promoters. The putative promoter region was subcloned into a vector...
the desmosomal cadherins desmoglein-2 (DSG2) and desmocollin-2, which extracellularly interact to form the intercellular adhesive interface and are intracellularly linked to desmin intermediate filament system via the adaptor proteins plakoglobin (PG), plakophillin-2 (PKP2) and desmoplakin (DP) [7]...
S.M. Troyanovsky, R.B. Troyanovsky, L.G. Eskind, R.E. Leube, W.W. Franke Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation Proc Natl Acad Sci USA, 91 (1994), pp. 10790-10794 Crossref...
Second, much evidence suggests that desmosomal cadherins interact at their tips or EC1 domains (14, 15, 16, 17, 26). Third, anti-adhesion peptides derived from the sequences of the so-called cell adhesion recognition sites in the EC1 domain block adhesion of both classical and desmosomal ...