differentiation (Watkinson, 1999). A pH gradient from the stratum basal (pH 7.4) of the epidermis to the outer SC (pH 4.5) (Ohman and Vahlquist, 1994) may trigger activity of extracellular cathepsin V (Watkinson, 1999). Its ability to degradein vitrodesmocollin-1 andcorneodesmosin, in ...
Apart from the type 2 isoforms, desmosomal cadherins are only expressed in stratified epithelia, in a differentiation-specific manner within the layers of the epidermis. Similar to classical cadherins, desmosomal cadherins have five EC repeats, a single transmembrane domain, and an intracellular ...
The defective skin barrier function, resulting from the loss of stratum corneum integrity, could result in typical compensatory mechanisms of adult epidermis. These include abnormal differentiation as well as hyperproliferation, accounting for acanthosis, and hyperkeratosis (Elias, 2005). The degradation ...