The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a challenge1–5. Here we describe a general solution to this problem that starts
Rationale and Design for a Higher (Dairy) Protein Weight Loss Intervention That Promotes Muscle Quality and Bone Health in Older Adults with Obesity: A Randomized, Controlled Pilot Study.Obesitymuscle qualityolder adultsprotein intakesarcopenic obesityweight loss intervention...
Successful materials design for bone-tissue engineering requires an understanding of the composition and structure of native bone tissue, as well as appropriate selection of biomimetic natural or tunable synthetic materials (biomaterials), such as polymers, bioceramics, metals and composites. Scalable fabri...
Therefore, in this review we expect to present recent progress of the design, synthesis, and healthcare applications of various functional protein hydrogels. For this aim, first we introduce the synthesis methods of protein hydrogels, including chemical, physical, and enzyme-induced formation strategies...
PEGylation in polymeric nanomedicine has gained substantial predominance in biomedical applications due to its resistance to protein absorption, which is c... H Dong,M Tang,Y Li,... - 《Nanomedicine》 被引量: 9发表: 2015年 Polypeptide-Based “Smart” Micelles for Dual-Drug Delivery: A Combin...
A fundamental question in protein evolution is whether nature has exhaustively sampled nearly all possible protein folds throughout evolution, or whether a large fraction of the possible folds remains unexplored. To address this question, we defined a set of rules for β-sheet topology to predict ...
T Naka - 《Tanpakushitsu Kakusan Koso Protein Nucleic Acid Enzyme》 被引量: 971发表: 2000年 SQ 14,225 (D-3-mercapto-2-methylpropanoyl-l-proline), a novel orally active inhibitor of angiotensin I-converting enzyme. Relatively potent and specific in vitro and in vivo inhibition of angiotensin...
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(Fig.3d). Luciferase was used as an internal control in these experiments because the same AVVs containing the same number of head particles and packagedLuciplasmid DNA molecules were used for testing each variable. The enhanced transduction was probably because the displayed protein molecules ...
Engineering micro–nanomaterials for biomedical translation. Adv. NanoBiomed Res. 1, 2100002 (2021). Article Google Scholar Choi, M. et al. Intracellular delivery of bioactive cargos to hard-to-transfect cells using carbon nanosyringe arrays under an applied centrifugal g-force. Adv. Healthc. ...