Clinical Trials Design and Interpretationprimary formal objectivehistorical controls methodbaseline comparisons methodregression to the meanarbitrary classificationvisual censorship formsimulated diastolic blood pressureconcurrent controlsSummary This chapter contains sections titled: Prefatory warning Introduction ...
The impact of these clinical trials is best evaluated by examining the substantial decline in mortality attributed to breast cancer in countries that have accepted and applied the results from Phase III clinical trials in the broader clinical setting [ 1 ]. Concomitant with the wider acceptance of...
Contemporary schema that classify evidence place results from randomized trials at the pinnacle of evidence. The primary objective of this article is to provide an overview of the design, conduct, and interpretation of trials with an emphasis on aspects that are relevant to nephrology. 展开 ...
(323)442-8295OfficeHours:ByappointmentBriefDescription:Thiscourseprovidesanintroductiontothefundamentalsofclinicaltrials,includingthedesign,conduct,analysis,andinterpretationoftrialresults.TopicsincludebriefintroductionofPhaseI&IIclinicaltrials,commonlyusedPhaseIIIclinicaltrials,protocolwriting,hypothesis,methodsof...
Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Disclaimer: ...
The BPI Interference subscale has demonstrated responsiveness to change in numerous clinical trials [[27], [28], [29]]. Table 3. Outcomes. DomainInstrument or data sourceLook-back periodScore rangeInterpretation of higher scoreAscertainment weeks Primary Outcome Pain interference Brief Pain Inventory ...
A fascinating and controversial approach to the design, monitoring, and interpretation of clinical trials is the use of a Bayesian approach. Compared with theclassicorfrequentistapproach described earlier, Bayesian methods formally use prior information specifying it as a prior probability distribution....
Factors influencing the conduct of a trial and the interpretation of results may be subtle and difficult to anticipate in the design stage. Nevertheless, general principles of trial design combined with the experience from previous beta-blocker trials should serve as a useful guide. Our discussion ...
Does a self-management intervention based on SMBP and self-titration medication allow for better control of blood pressure? 2. What is the impact of this intervention on adherence to treatments, lifestyle changes, quality of life, clinical outcomes and use of health services? 3. Is this inter...
The heterogeneity of human clinical trials to assess the effectiveness of probiotics presents challenges regarding interpretation and comparison. Evidence obtained from clinical trials among a population with disease or specific risk fac... AL Shane,MD Cabana,S Vidry,... - 《Gut Microbes》 被引量:...