A Study to Assess the Efficacy and Safety of CBP-201 in Adult Subjects With Moderate to Severe Atopic Dermatitis. Accessed November 3, 2023. https://clinicaltrials.gov/study/NCT04444752 31. Beck LA, Thaçi D, Hamilton JD, et al. Dupilumab treatment in adults with moderate-to-...
Hamilton JD, Suárez-Fariñas M, Dhingra N, et al. Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis. J Allergy Clin Immunol. 2014;134(6):1293-1300. doi:10.1016/j.jaci.2014.10.013 PubMedGoogle ScholarCrossref 44...
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The guinea pig maximization test is an adjuvant sensitization test requiring intradermal injections of the test substance, in combination with Freund's complete adjuvant, which stimulates non-specifically the immune system of treated animals, enhancing their ability to respond to sensitizing chemicals. ...
Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid). N Engl J Med. 1993;329(8):530-535. doi:10.1056/NEJM199308193290803 PubMedGoogle ScholarCrossref 12. Cho S, Lowe L, Hamilton TA, Fisher GJ, Voorhees JJ, Kang ...
Cho SLowe LHamilton TAFisher GJVoorhees JJKang S Long-term treatment of photoaged human skin with topical retinoic acid improves epidermal cell atypia and thickens collagen band in the papillary dermis. J Am Acad Dermatol 2005;53769- 774PubMedGoogle ScholarCrossref 15. Kang SKrueger GTanghetti...
in populations along the ancient ‘Silk Road’, extending from Eastern Asia to countries in the Middle East and the Mediterranean, compared with Western countries, but has universal distribution. Mucocutaneous manifestations are the clinical hallmarks of BD. The diagnostic criteria widely used in the ...
Atopic dermatitis (AD) is a common chronic inflammatory skin disease that predominantly affects children. However, it can persist in adulthood and/or start at older ages. Due to its chronic nature and frequently occurring relapses, AD has a substantial effect on patients' quality of life, often...
Two phase 3 trials of dupilumab versus placebo in atopic dermatitis. N Engl J Med. 2016;375(24):2335-2348. doi:10.1056/NEJMoa1610020 PubMedGoogle ScholarCrossref 34. Beck LA, Thaçi D, Hamilton JD, et al. Dupilumab treatment in adults with moderate-to-severe atopic...
Lambert CAColige ACLapiere CMNusgens BV Coordinated regulation of procollagens I and III and their post-translational enzymes by dissipation of mechanical tension in human dermal fibroblasts. Eur J Cell Biol 2001;80479- 485PubMedGoogle ScholarCrossref 22. Orringer JSVoorhees JJHamilton T et al...