studies of depression in central nervous system (CNS) disorders are scarce, it is hoped that a thorough knowledge of the appearance and treatment of idiopathic depressive disorders will provide a useful template and model for diagnosis and treatment of depression in patients with a CNS disorder.doi...
Depressive disorder, a debilitating psychiatric disorder, is the leading cause of disability worldwide [1]. The World Health Organization (2019) estimates the global loss in productivity due to depressive disorders amounts to $1 trillion per year –a trajectory expected to rise [2]. Compositional ...
New combinations or alternative therapies for major depressive disorder (MDD) are necessary. Intradermal acupuncture (IA) shows promise but requires further investigation regarding its efficacy, safety, and mechanisms. Conducted across 3 centers from November 2022 to January 2024, our randomized controlled...
The neuropathology of mood disorders, including the diagnostic transition from major depressive disorder (MDD) to bipolar disorder (BD), is poorly understood. This study investigated resting-state electroencephalography (EEG) activity in patients with MDD and those whose diagnosis changed from MDD to ...
Although emotion regulation can be affected both by major depressive disorder (MDD) and by cannabis use, the relationship among all three factors is unknown. In this study, we used fMRI to evaluate the effect that cannabis use and MDD have on brain activation during an emotion regulation task....
Previous studies in small samples have identified inconsistent cortical abnormalities in major depressive disorder (MDD). Despite genetic influences on MDD and the brain, it is unclear how genetic risk for MDD is translated into spatially patterned corti
Efforts to develop neuroimaging-based biomarkers in major depressive disorder (MDD), at the individual level, have been limited to date. As diagnostic criteria are currently symptom-based, MDD is conceptualized as a disorder rather than a disease with a
Recently, we reported an emotion self-regulation study (Zotev et al., 2020), in which patients with major depressive disorder (MDD) used simultaneous real-time fMRI and EEG neurofeedback (rtfMRI-EEG-nf) to upregulate two fMRI and two EEG activity measures, relevant to MDD. The target meas...
Major depressive disorder (MDD) is a heterogeneous clinical syndrome with widespread subtle neuroanatomical correlates. Our objective was to identify the neuroanatomical dimensions that characterize MDD and predict treatment response to selective seroton
HC, healthy control; MDD, major depressive disorder; NAc, nucleus accumbens. Neuropsychopharmacology Accumbens and ketamine in MDD CG Abdallah et al 1742 correlations between left NAc and PSWQ or between left or right NAc and HDRS or HAM-A (all p-values40.05). In the follow-up subgroup ...