Forty-five patients (aged 19-51 years) with moderate to severe (Hamilton score >18) recurrent major depressive disorder (DSM-IV) were compared to 50 healthy controls matched on age, education, gender and intellectual abilities. The subjects were administered a set of neuropsychological tests that...
Major depressive disorder-recurrentA condition defined as A. 2 or more major depressive episodes–MDE, which is defined as ≥ 5 of the following present during the same 2-week period, and represent a change from previous functioning and at least one of the 5 is either ...
In conclusion, a single dose of intravenous ketamine delivered during surgical anesthesia had no greater effect than placebo in acutely reducing the severity of depressive symptoms in adults with major depressive disorder. This trial successfully masked treatment allocation in patients with moderate-to-...
系统标签: depression recurrent depressive bipolar spectrum major MajorDepressiveDisorder–RecurrentDepressionand BipolarSpectrum Dr.Marks:Thelearningobjectivesfortoday'seventaretointegrateguidelines-basedmajor depressivedisorder(MDD)careintodailypractice,includingregularmeasurementofsymptoms andseverity;employevidence-based...
Although common, depression is often ignored or wrongly diagnosed and left untreated. This can be life-threatening;major depression, in particular, has a high suicide rate. If you or a loved one have symptoms of depression, seek help from a qualified health care professional. Many primary care...
Background: Information on the distribution of disability associated with major depression (MD) across different groups of patients is of interest to health policy and planning. We examined the associations of severity and type (a single or recurrent episode) of MD with disability in a Dutch gener...
RST has been shown to predict prolonged depression in samples of non-clinical, untreated individuals with mild to moderate depression but has not been tested in samples of depressed patients undergoing treatment. In this preliminary investigation we examined: (1) whether RST predicts non-response to...
It is also called major depression. Depressive episodes also occur in bipolar disorder, a condition marked by periods of depression interspersed with periods of high-energy mania. People swing between the two poles of mood states, sometimes over the course of days, and sometimes over years, ...
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry 2011; 16: 2–4. 142 Green EK, Grozeva D, Jones I, Jones L, Kirov G, Caesar S et al. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major ...
free radical production and brain damage by increasing neurodegeneration and impairing neurogenesis.41Chronic inflammation as well as oxidative and nitrosative stress has long been hypothesized to play a role in recurrent major depression and especially in neurocognitive deficits.31,41Cellular redox status ...