(2)生化因素:儿茶酚胺假说:主要指抑郁症的发生可能与大脑突触间隙神经递质5-羟色胺(5-HT)和去甲肾上腺素(NE)的浓度下降有关;由于很多抗抑郁剂,如选择性5-羟色胺再摄取抑制剂(SSRI)或者选择性5-羟色胺和去甲肾上腺素再摄取 展开全部内容
45-51.Sharp T & Cowen PJ (2011) 5-HT and depression: is the glass half-full? Curr Opin Pharmacol 11, 45 -51.Sharp;T;Cowen;PJ.5-HT and depression:is the glass half-full.Current Opinion in Pharmacology.2011Sharp, T. and Cowen, P.J. (2011). 5-HT and depression: is the glass...
The molecular pharmacology, functional role and behavioural implications of central 5-HT1B/1D receptors suggest that these particular receptor subtypes probably play an important role in brain serotonin neurotransmission. This article summarises the rationale for considering 5-HT1B/1D antagonists as ...
1.1.2试剂5-HT盐酸盐(批号:H9523),2,3-二羟基苯甲酸(批号:857 7),三乙胺(色谱纯,批号 65897),不同频率电针镇痛抗抑郁效应观察和对中枢5-HT的影响吴媛媛赵晓芸蒋永亮方剑乔浙江中医药大学第三临床医学院针灸神经生物实验室杭州310053摘要:[目的]观察不同频率电针对健康大鼠 镇痛抗抑郁效应及其与中枢5羟色胺(...
5-HT5A receptor antagonists; depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, drug withdrawal US ...
・基础研究・・论著・快速眼动睡眠剥夺对抑郁模型大鼠纹状体5‐HTDA及腺苷的影响△冯飞 许崇涛 徐国建 吴东辉作者简介:冯飞,男,32岁,汉族,硕士,主治医师。主要研究成果:参与国家自然科学基金资助项目1项,广东省科技计划项目1项,深圳市科技计划项目3项。研究方向:生物精神病学。【摘要】目的 通过对抑郁模型大鼠...
An open study of 20 69–93-yr-old depressed and physically ill hospitalized patients was conducted to assess the efficacy and safety of the 5-hydroxytryptamine (5-HT) reuptake inhibitor, fluoxetine. Eight patients had died within 3 mo from progression of their physical pathology. Of those who ...
Alterations in 5-HT1B Receptor Function by p11 in Depression-Like States The pathophysiology of depression remains enigmatic, although abnormalities in serotonin signaling have been implicated. We have found that the serotonin 1... Svenningsson,P. - 《Science》 被引量: 1325发表: 2006年 Down-...
One prominent finding was the anxiolytic ability of the 5-HT 2C R agonist and the anti-depressive ability of the 5-HT 2C R antagonist on the 7 th -day treatment. Though the exact mechanism of action is not clear, their ability to equilibrate brain redox status, restoring Ca 2+ level ...
（comorbidanxietyanddepression）焦虑与抑郁的联系 焦虑症 •过度担忧•神经系统症状(如头晕、震颤)•大汗•口干•坐立不安•呼吸急促•睡眠障碍•食欲改变•心血管/消化系统症状•注意力障碍•易激惹•精力减退 抑郁症 •抑郁心境•无价值感/罪恶感•自杀观念 5-HT能神经系统方面、促肾上腺皮质...