Sharp T,Cowen PJ.5-HT and depression:is the glass half-full. Current Opinion in Pharmacology . 2011Sharp T;Cowen PJ.5-HT and depression: is the glass half-full?,2011Sharp T,Cowen PJ.5-HT and depression:is the glass half-full.Current Opinion in Pharmacology. 2011...
机理:阻止5-HT和NA(Norepinephrine,去甲肾上腺素)的重吸收,提高细胞间HT和NA的浓度。低浓度SNRI与SSRI类似,中浓度可以同时抑制HT和NA重吸收,高浓度可以抑制DA(Dopamine,多巴胺)的重吸收。可降低疲劳感、提高注意力。 药物列表: Desvenlafaxine (去甲文拉法辛)50-100mg Venlafaxine (文拉法辛)75-225mg Duloxetine (...
5-HT1B, 5-HT4, 5-HT6, and 5-HT7. 5-HT1Areceptors (5-HT1ARs) exist in two distinct populations: 1) as somatodendritic autoreceptors on the raphe nuclei neurons that produce 5-HT, and 2) as postsynaptic heteroreceptors that mediate local neuromodulatory effects in several ...
The molecular pharmacology, functional role and behavioural implications of central 5-HT1B/1D receptors suggest that these particular receptor subtypes probably play an important role in brain serotonin neurotransmission. This article summarises the rationale for considering 5-HT1B/1D antagonists as ...
AnxietyandDepression 焦虑 •焦虑是指一种缺乏明显客观原因的内心不安或无根据的恐惧，预期即将面临不良处境的一种紧张情绪，表现为持续性精神紧张（紧张、担忧、不安全感）或发作性惊恐状态（运动性不安、小动作增多、坐卧不宁、或激动哭泣），常伴有自主神经功能失调表现（口干、胸闷、心悸、出冷汗、双手震颤、厌食...
The new “5-HT” hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression....
A dual-template molecularly imprinted electrochemical sensor was developed for the simultaneous detection of serotonin (5-HT) and glutamate (Glu). First, amino-functionalized reduced graphene oxide (NRGO) was used as the modification material of a GCE to increase its electrical conductivity and specif...
Dorsal raphe nucleus; 5-Hydroxyindoleacetic acid; 5-Hydroxytryptamine; 5-Hydroxytryptophan; NSD 1015; Pargyline Abstract: The activity of 5-hydroxytryptaminergi... NJ Shannon,JW Gunnet,KE Moore - 《Journal of Neurochemistry》 被引量: 355发表: 1986年 5-HT activates neural reflexes regulating secret...
An open study of 20 69–93-yr-old depressed and physically ill hospitalized patients was conducted to assess the efficacy and safety of the 5-hydroxytryptamine (5-HT) reuptake inhibitor, fluoxetine. Eight patients had died within 3 mo from progression of their physical pathology. Of those who ...
In the mouse model, the TPH2 gene and 5-HT can be regulated by gene therapy, but these methods can only be used in the mouse model, and there is still no direct treatment for depression by CRISPR technology. We hope to be able to apply these methods to the treatment of human ...