Cyclin-dependant kinase 4 (CDK4) and CDK6 phosphorylate the tumour suppressor retinoblastoma protein (RB), resulting in the release of the E2F transcription factor and progression through the cell cycle. CDK4 and CDK6 are positively regulated by D-type cyclins (that is, cyclin D1, cyclin D2...
TNBC cells are characterized by Notch-dependant IL1β expression and Notch-independent expression of caspase-18,9, both prerequisites for IL1β maturation and the recruitment of pro-tumoral TAMs to the tumor microenvironment. Here we established in a large survey of breast cancer cell lines11 and...
In the followed experiment, the total polyphenol compounds in the LFBE exhibited dramatic anti-lipogenic effects in a manner of dosage-dependant (Figure 3A). In addition, ferulic acid and vanillic acid isolated from LFBE using HPLC also held the abilities to decrease fat accumulation at the conc...