insulin receptor substrates (IRS)14, and others have suggested that insulin and IGF-1 are able to induce overlapping, but distinct, patterns of gene expression15,16,17. Studies using chimeric receptors have suggested that the IGF1R intracellular domain (IGF1R-ICD) may be more important for ...
decre.~scdfilucosc o h i d a l ~ oa~pipeared only afler #.Iy o f obesily, nlld wo~serlvci v i l l l ubeblly d u ~ n t ) o >(1l-=0.7?, p<.OOOi) We h y p o l i l c s i ~ cIlia1 i~lcrc,~scdl > p i i Iohid,lllcln ircini; one d IcdcI l o ...
Consequences of smoking for body weight, body fat distribution, and insulin resistance The American Journal Of Clinical Nutrition, 87 (4) (2008), pp. 801-809 View PDFView articleView in ScopusGoogle Scholar Cochrane et al., 1998 C. Cochrane, R. Malcolm, T. Brewerton The role of weight co...
Figure 1. Elevated Oleate (C18:1)-Enriched Hepatic Neutral Lipids and Insulin Resistance in T5KO Mice (A–F) Age-matched T5KO male mice and their WT littermates (20 week old, n = 10 to 11) were monitored for (A) body weight, (B) fat pad, (C) 15 hr fasting blood glucose, (...
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol 2003; 2: 20. 23. Birkenkamp KU, Coffer PJ. Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead ...
www.nature.com/scientificreports OPEN 1,25(OH)2D3 dependent overt hyperactivity phenotype in klotho- hypomorphic mice received: 15 December 2015 accepted: 05 April 2016 Published: 25 April 2016 Christina B. Leibrock1, Jakob Voelkl1, Makoto Kuro-o2, Florian Lang1 & Undine E ...
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They are namely the sirtuin family of proteins, IlS (the insulin/insulin-like growth factor) signaling pathway, and the target of rapamycin (TOR) pathway [75,78,79]. The elements of these pathways likely differ between individuals of the D and H strains. Therefore, their life expectancy ...
The digestion of PYC in the presence of enzymes and microbiota resulted in increased IL-10 production and alterations in microbiota indicative of immunomodulatory activity of the PYC hydrolysates. 2. Materials and Methods 2.1. Preparation of Samples and PYC-LPS Complexes PYC was obtained from Horphag...