LINEs are the most diverse TE type in the E. hecabe genome, with 385 distinct LINE families identified by our analysis. A repeat landscape analysis suggests a gradual increase in TE activity over time, followed by a slight recent decline in activity (Additional file 1: Figure S3). Consistent...
who straddle the Gen Z and millennial generations, are more likely to have college educations than their parents. For instance, 40% of adults between 25 and 29 have a college degree today, compared with 24% of the same age group in 1993. ...
The lifespan of flies exposed to BL even at the young age was significantly reduced (by 6%) compared to the control in DD (p < 0.001; Fig. 1C). Moreover, the lifespan of flies exposed to the same BL conditions at the middle age was further reduced by 15% compared to DD ...
How the central nervous system (CNS) controls many joints and muscles is a fundamental question in motor neuroscience and related research areas. An attractive hypothesis is the module hypothesis: the CNS controls groups of joints or muscles (i.e., spati
[43]. Thus, thedmygene is necessary for the development of males in medaka. Moreover, over-expression ofdmyby injectingdmygenomic DNA fragment into XX female eggs or over-expression of thedmycDNA under the control of the CMV promoter in XX females resulted in XX individuals developing into ...
Animals were treated in compliance with the US Department of Health and Human Services and Baylor College of Medicine guidelines. 2.2. Retinal injections of lipophilic dye Neonatal (P6/7) mice are anesthetized using a combination of ketamine, xylazine, and acepromazine supplemented with hypothermia. ...
Models of sequence evolution typically assume that different nucleotide positions evolve independently. This assumption is widely appreciated to be an over-simplification. The best known violations involve biases due to adjacent nucleotides. There have a
We also sought to identify the mechanism by which loss of Upf2-dependent NMD leads to these neurodevelopmental impairments in mice. Integrating multiple approaches such as transcriptomics, flow cytometry, immunohistochemistry, pharmacology, and behavior, we provide causal evidence that over-activation of ...
invasion and progression12. Moreover, proteases secreted by CAFs cleave and activate growth factors, cytokines, and cell adhesion molecules (CAMs) embedded in the ECM, increasing cancer cell motility and EMT6. Unlike cancer cells, CAFs are genomically stable, and do not harbor oncogenic mutations ...
In the first dataset, we modelled fossil preservation as a function of a time-variable Poisson process. Preservation rates were allowed to vary every 1 million years. In the second dataset, we allowed fossil preservation to vary over the course of a species’ lifespan by modelling it with a...