was funded by the Canadian Institutes of Health Research (CIHR) grant MOP-133711 to R.A., a Canada Foundation for Innovation (CFI) equipment grant Fonds des leaders 29970 to R.A., and a Natural Sciences and Engineering Research Council of Canada (NSERC Discovery Grant) grant application no....
Nuclear Pore complexes (NPCs) act as docking sites to anchor particular DNA lesions facilitating DNA repair by elusive mechanisms. Using replication fork barriers in fission yeast, we report that relocation of arrested forks to NPCs occurred after Rad51
At the beginning of a time step, the flow field in the bottom boundary layer is determined for specified wave and current conditions using a standard wave–current interaction model applied to each location along the model transect (e.g., Smith, 1977; Grant and Madsen, 1979). Next, the ...
The research leading to these results has received the funding from the European Community's Horizon 2020 Program ([H2020/2014-2019]) under Grant Agreement no. 674973 (MSCA-ETN DEMETER). Project website: http://etn-demetereu/. This publication reflects only the authors' views, which are tar...
If a food spot is attractive because of the odours emitted but turns out to be distasteful and/or poisonous, the aggregate will probably not form. In this report, we designed tests derived from protocols described in our previous publication in order to analyze this stereotyped task [1]. We...
α-syn application The monomeric form of α-syn (α-synM) was stored in solution at -20oC in aliquots of 10 µl (150 µM) until use at which time it was applied via the bath. To reach a final concentration of 100 nM, an aliquot (150 µM) of 10 µl of α-synMwas dilu...
from which it becomes clear that, depending on the specific choice of\(\beta _\text {vi}\), fracture is driven by stored strain energy and the free energy contribution related to a portion of accumulated viscous dissipation. It has to be noted that in the present form (36), the evolutio...
Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don’t respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response to checkpoint-based immunotherapy. Based on in vitro pharmacological studies...
Its internal do novo RNA initiation from the 83-nt RNA template suggests that JEV RNA replicase complex might require viral and/or cellular proteins to direct RNA synthesis initiation form the 3'-end in vivo. The recombinant JEV NS5 protein will facilitate the analysis of the roles of such ...
(Supplementary Fig.6). These findings were in contrast to other, significantly shorter RiPP leader peptides that form random coils or singular transiently stable amphipathic helices25,26,27,28,29. Driven by these spectroscopic hints at the possible structural features of proteusin leaders, we ...