Depatuxizumab(depatux,以前称为ABT-806)是一种人源重组单克隆抗体,最初是针对 EGFRvIII在小鼠中生成的,尽管当野生型EGFR存在且高水平时它也能结合到野生型EGFR上。当EGFR被激活时,抗体才能与其相结合。抗体药物结合物(ADC)depatuxi...
Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEDepatuxizumabmafodotinCat.No.:HY-132259CASNo.:1585973-65-4Synonyms:ABT-414作用靶点:Antibody-DrugConjugates(ADCs);EGFR作用通路:Antibody-drugConjugate/ADCRelated;JAK/STATSignaling;ProteinTyrosineKinase/RTK储存方式:Pleasestoret...
UNII号 F3R7A4P04N 化学名 DEPATUXIZUMAB MAFODOTIN CAS号 1585973-65-4 结构式图片 NCIT码 C105612 INN_ID 10263 别名 ABT-414 中文名 玛汀-迪妥昔珠单抗 扩展信息 VIP试用医疗器械查询APP下载客服中心常见问题数据可视化数据分析挖掘系统网站地图业务介绍友情链接 400-678-0778 ...
UNII号 F3R7A4P04N 化学名 DEPATUXIZUMAB MAFODOTIN CAS号 1585973-65-4 结构式图片 NCIT码 C105612 INN_ID 10263 别名 ABT-414 中文名 玛汀-迪妥昔珠单抗 扩展信息 VIP试用医疗器械查询APP下载客服中心常见问题数据可视化数据分析挖掘系统网站地图业务介绍友情链接 400-678-0778 ...
Depatuxizumab Mafodotin (ABT-414)由Abbvie公司研发,管线生存期为2013-2019年。ABT-414靶向表皮生长因子受体(EGFR),其主要适应症为星形胶质瘤。ABT-414主要由ABT-806和MMAF通过不可裂解Linker (Maleimido Caproyl, MC)偶联组成,其偶联方式为非特异性链间Cys偶联,DAR~3.8[15]。
CSIG-06. DEPATUXIZUMAB MAFODOTIN (ABT-414)-INDUCED GLIOBLASTOMA CELL DEATH REQUIRES EGFR OVEREXPRESSION, BUT NOT PHOSPHORYLATIONGlioblastomas commonly (40%) exhibit epidermal growth factor receptor (EGFR) amplification, half of these tumors... VA Caroline,B Vincent,W William,... - Neuro-Oncology...
ACTR-21. A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 3 TRIAL OF DEPATUXIZUMAB MAFODOTIN (ABT-414) IN EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AMPLIFIED (AMP) NEWLY DIAGNOSED GLIOBLASTOMA (nGBM)doi:10.1093/neuonc/noz175.064BACKGROUND. Approximately 50% of nGBMs harbor EGFR-amp. Depa...
Depatuxizumab mafodotin (ABT-414) is an antibody drug conjugate consisting of the monoclonal antibody 806 and, as its toxic payload, monomethyl auristatin F, designed to target EGFR-overexpressing tumor cells. Since long-term glioma cell lines and patient-derived glioma-initiating cell lines ...
Product Name Depatuxizumab mafodotin (ADC) Host Species nan Applications Research Grade Biosimilar Species Reactivity Human Target EGFR/ERBB1 Clonality Monoclonal Alternative Names ABT-414 公司简介 普健生物(武汉)科技有限公司于2012年在武汉成立,作为武汉国家生物产业基地指定的光谷抗体发现与筛选公...
Depatuxizumab mafodotin - AbbVie Alternative Names: ABT-414; ABT-414/806; Depatux-M Latest Information Update: 15 Dec 2023 Price : €55 * Buy Profile Note: Adis is an information provider. We do not sell or distribute actual drugs. Final gross price and currency may vary ac...