Dengue virus (DENV), a positive-sense (+) single-stranded RNA virus belonging to the Flavivirus family, has spherical-shaped envelope virion particles with surface proteins arranged in icosahedral symmetry [1,2]. The viral genome is about 11 kb long and is translated directly upon entering host...
50% tissue culture infectious doses (TCID50) were determined likewise, with ten-fold serial dilution of virus in the absence of antibody/plasma. Immunofluorescence Assay Tissues were fixed in 10% neutral buffered formalin, and immunofluorescence was performed on 5 μm paraffin-embedded sections. ...
El virus del dengue se propaga con mayor frecuencia a un humano a través de la picadura de un mosquito infectado. Los mosquitos por lo general se encuentran cerca del agua. Unos ejemplos incluyen estanques, agua en baldes, recipientes de comida para animales y macetas. El número de ...
A vaccine called Dengvaxia can help prevent dengue in children aged 6 to 16 who have tested positive for the virus before and who live in areas where dengue spreads. The vaccine is about 80% effective, but children need three doses to get full protection against the virus. ...
Dengue virus (DENV) utilizes the endoplasmic reticulum (ER) for replication and assembling. Accumulation of unfolded proteins in the ER lumen leads to ER stress and unfolded protein response (UPR). Three branches of UPRs temporally modulated DENV infecti
Entry of the dengue virus (DENV) into a host cell is mediated by its major envelope protein, E. The crystal structure of the E protein reveals a hydrophobic pocket occupied by the detergent n-octyl-尾-d-glucoside (尾-OG) lying at a hinge region between domains I and II, which is ...
non- outbreak period in Dar Es Salaam, Tanzania: a cross-sectional survey Ummul-khair Mustafa1*, Katharina Sophia Kreppel1,2 and Elingarami Sauli1 Abstract Background Tanzania has experienced multiple dengue outbreaks between 2010 and 2019, caused by various dengue virus (DENV) strains...
Following uptake and fusion of the virus and host cell membranes, its fluo- rescence unquenches, allowing discrimination of DiD-particles using Nanosight under fluorescence mode. The modal size of DiD-particles was 2 to 3 fold larger than modal size of nanoparticles detected under ...
Dengue virus belongs to the class of RNA viruses and subclass of enveloped single-stranded positive-sense RNA virus. It causes dengue fever (DF), dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS), where DHF and DSS are life-threatening. Even though dengue is an age-old di...
Targeting mosquito control to high-risk spread routes at both origin and destination could achieve similar levels of containment and should be studied as a future arbovirus containment strategy. The modelling approach developed here could also be adapted to understand the spread of other EIDs by re...