One study estimates that approximately 390 million dengue infections occur per year (95% CI; 284-528 million), with 96 million of these presenting clinically.[49] An estimated 2.5-3 billion people (approximately 40%-50% of the world’s population) are estimated to be at risk for dengue ...
The incidence rate of dementia was higher in female (4.91 per 1000 person-years) than in male (4.28 per 1000 person-years). Higher risks of dementia were observed in the elderly population: participants aged 60–69 years had a HR of 3.80 (95% CI= 2.08–6.93, p-value <0.001) and ...
However, we did not find a relation between the immune response and the evolution to death (Table 2). Except by the year 2008, when most deaths were due to secondary infections, during the most expressive epidemic years 2002, 2010, 2011, 2012 and 2013, fatal cases were mainly due to ...
The infection rate worldwide has been rising, promptingnew efforts to fight it. However, dengue is rare in the U.S. and its territories, with only 583 locally acquired cases reported so far this year, according to CDC data: 520 in Puerto Rico, 62 in Florida and one in Texas. The new...
It is estimated that more than 50 million infections occur each year, including 500,000 hospitalizations for dengue haemorrhagic fever, mainly among children, with the case fatality rate exceeding 5% in some areas1–4. The annual average number of dengue fever/den- gue haemorrhagic fever (DF/...
Global deaths due to dengue have increased by nearly 50%, resulting in approximately 18,500 deaths each year (GBD 2015 Mortality and Causes of Death Collaborators, 2016). Furthermore, dengue poses a substantial economic burden on individuals and governments, and is a barrier to economic ...
The age-specific morbidity rate was highest in the 10- to 19-year age group followed by the 20- to 29-year age group. Epidemics of dengue fever were found to occur seasonally with the appearance of two peaks, viz. one in June and the other in August. Dengue fever, a rural disease ...
Although long overdue, the development of a safe and effective dengue vaccine is moving forward at an unprecedented rate, mainly owing to the use of reverse genetics and the availability of Vero cells for manufacture, with a high likelihood that the challenges of vaccine development and ...
including the Caribbean and India. Climate change may be responsible for dengue encroaching into southern Europe. There are an estimated 40 million symptomatic cases per year. Dengue has fourserotypes, all of which cause disease. Interestingly, infection with oneserotypeis not only not protective of...
Infection has doubled over the past two decades, currently totaling 50–100 million per year.2 These viruses regulate the metabolism and survival of infected cells, assuring their own reproduction and propagation. Dengue infection also triggers autophagy, a general homeostatic response that helps the...