The present invention it was determined that dendritic cells could be derived from various sources including peripheral blood monocytes in the presence of only GM-CSF without other cytokines if the monocytes were not activated. By preventing activation, such as by preventing binding of the cells to...
LCs are bone-marrow–derived dendritic cells that migrate to and reside in the epidermis, where they sample antigen and constitutively migrate out of the skin in low numbers to the DLNs [1]. From:Immunology and Allergy Clinics of North America,2003 ...
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et al. Defective generation and maturation of dendritic cells from monocytes in colorectal cancer patients during the course of disease. Int. J. Mol. Sci. 14, 22022–22041 (2013). PubMed PubMed Central Google Scholar van Willigen, W. W. et al. Dendritic cell cancer therapy: vaccinating ...
Dendritic CellsDefinition, Production, Function and ImmunologyDendritic Cell Illustration by XcepticZP [Public domain] Derived from precursors in the bone marrow, dendritic cells (DC) are professional antigen-presenting cells typically found in the mucosa, skin, and lymphoid tissues. As antigen-...
Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6. Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6. J Immunol 163:.....
Monocytes can differentiate into dendritic cells (DC), cells with a pivotal role in both protective immunity and tolerance. Defects in the maturation or function of DC may be important in the development of autoimmune disease. We sought to establish if there were differences in the cytokine (gran...
Dendritic cells and monocyte-derived cells: two complementary and integrated functional systems. Semin. Cell Dev. Biol. 41, 9–22 (2015). Article CAS PubMed Google Scholar Böttcher, J. P. & Reis e Sousa, C. The role of type 1 conventional dendritic cells in cancer immunity. Trends ...
Myeloid-Derived Suppressive Cells and Their Regulatory Mechanisms in Cancer In general, MDSCs are a heterogeneous population of immature myeloid cells (IMCs) that comprises myeloid progenitor cells, immature macrophages, immature granulocytes, and immature dendritic cells (DCs). They are present in an ...
(both conventional and plasmacytoid) found in blood. These cytokines are produced by various tissue stroma including fibroblasts, endothelial cells, macrophages, mast cells, NK cells, and activated T Cells. DCs can also be derived from monocytes in vitro by treating them ...