Recent advances in our understanding of the different types of DC subsets along with the cellular organization and orchestration of DC and lymphocyte positioning in secondary lymphoid organs over time has led to a clearer understanding of how the nature of the T cell response is shaped. This ...
Dendritic cell subsets in T cell programming: location dictates function Article21 November 2018 Main Ralph Steinman described dendritic cells (DCs), as they are now recognized, in the 1970s and showed that they are potent accessory cells involved in the induction (priming) phase of the immune r...
Dendritic cell maturation in cancer Dendritic cells (DCs) shape the adaptive immune response to peripheral tissue antigens and, as such, are crucial for mounting an effective antitumour immune response in cancer. This Review outlines the molecular basis of DC maturation, highlights the mechanisms thr...
Dendritic cell subsets and surface markers in BALF and in peripheral blood were analysed using four-colour flow cytometry. RESULTS: Plasmacytoid dendritic cells (pDCs, median 0.06%, range 0.01-0.08%) and myeloid dendritic cells (mDCs, median 0.47%, range 0.27-0.87%) were detectable in BALF ...
In 1868, Paul Langerhans discovered the first immune cell during a study of the skin. The cells he discovered, dendritic cells (DCs), were named for their long projections that made them resemble the dendrites of nerve cells, which was the function Langerhans assigned to them at that time. ...
Phthalate esters with short alkyl chains, such as di-ethyl (DEP), di-n-propyl (DPP), and di-butyl phthalate (DBP), have adjuvant effects on an FITC-induced contact hypersensitivity mouse model. The adjuvant effects of DPP and DBP are associated with enhanced trafficking of FITC-presenting CD...
Dendritic cells (DCs) act as gatekeepers between immunity and tolerance. Initially, it was postulated that mature DCs promote effector T cell responses and immature DCs promote tolerance. Recent studies have shown instead that two distinct modes of DC maturation exist — homeostatic and immunogenic. ...
Distinct functions of specialized dendritic cell subsets in atherosclerosis and the road ahead. A. Zernecke, Distinct functions of specialized dendritic cell subsets in atherosclerosis and the road ahead, Scientifica 2014 (2014) 952625... Alma,Zernecke - 《Scientifica》 被引量: 6发表: 2014年 Dist...
from common bone marrow progenitors to multiple subsets in peripheral tissues D Sichien1,2, BN Lambrecht1,3,4, M Guilliams1,2 and CL Scott1,2 Our understanding of conventional dendritic cell (cDC) development and the functional specializations of distinct subsets in the peripheral tissues has in...
We have seen that different types of macrophages exist. These include proinflammatory M1 and antiinflammatory M2 phenotypes, as well as a variety of different tissue-resident macrophages. Different subsets andlineagesof dendritic cell also exist. As mentioned inSection 2, there are two main types of...