Demyelination of the brain in tuberous sclerosis: computed tomography evidence.doi:10.1097/00004728-198006000-00026BurkeDennis P.Journal of Computer Assisted Tomography
Noun1.demyelination- loss of the myelin covering of some nerve fibers resulting in their impaired function degenerative disorder- condition leading to progressive loss of function disseminated multiple sclerosis,disseminated sclerosis,MS,multiple sclerosis- a chronic progressive nervous disorder involving loss...
Another commonly used model involves oral administration of the toxin cuprizone (oxalic acid bis (cyclohexylidene hydrazide)) that induces oligodendrocyte cell death, myelin membrane vacuolization, and demyelination in specific white matter tracts of the brain (i.e. cerebellar peduncles, corpus callosum...
previously demonstrated to have deficient MAT activity in his liver, has normal brain myelination on MRI and normal neurological function, despite being homozygous for a 539 TG insertion in exon V of MAT1A, so that the gene is predicted to encode a protein of only 184 rather than the normal...
In addition to the direct effect of cuprizone on oligodendrocytes, the involvement of the brain’s resident neuroinflammatory cells such as microglia and astrocyes is also believed to be responsible for the massive demyelination occurring at 4 weeks time point of cuprizone exposure [18]. Important...
Objective To study the clinical value of 1H-magnetic resonance spectroscopy (1H-MRS) in differential diagnosis of brain low-grade gliomas and demyelinating diseases. 目的探讨氢质子磁共振波谱(1H-MRS)在低级别胶质瘤与脱髓鞘病变鉴别诊断中的应用价值。 更多例句>> 3) demyelination [英][di:,maiəl...
Metachromatic leukodystrophy (MLD) is a severe demyelinating, autosomal recessive genetic leukodystrophy. The disease is underpinned by mutations in the arylsulfatase A gene (ARSA), resulting in deficient activity of the arylsulfatase A lysosomal enzyme and consequential accumulation of galactosylceramide-3-...
The consistent increases in phosphatidylcholine VLCFA in all samples from the ALD brain, which are postulated to represent progressive stages in the development of the disorder, suggest that phosphatidylcholine may be involved in antigen formation and may underlie an immunological basis for the ...
Here, we examined the effects of rHIgM22 in remyelination in the brain using the mouse model of cuprizone-induced demyelination, which is characterized by spontaneous remyelination. The myelination state of the corpus callosum of cuprizone-fed mice treated with rHIgM22 was examined immediately ...
Blood-derived macrophages also enter the CNS due to compromised blood–brain barrier integrity in MS. Macrophages take on many of the same roles as microglia, however, some studies suggest that these infiltrating peripheral cells are more pathogenic in MS/EAE compared to resident microglia18,19. ...