Several central nervous system (CNS) demyelinating disorders have been described in humans including, multiple sclerosis (MS), neuromyelitis optica (Devic's disease), acute disseminated encephalomyelitis, and osmotic demyelination (central pontine myelinolysis, extrapontine myelinolysis). The primary cellular...
Multiple sclerosis1 (MS) is an immune-mediated autoimmune demyelinating disease in humans. The initiating event in MS is unknown, but epidemiological evide... JK Olson,AM Ercolini,SD Miller - 《Current Topics in Microbiology & Immunology》 被引量: 273发表: 2005年 Multiple sclerosis: lessons fro...
Progressive multifocal leukoencephalopathy is a deadly demyelinating disease of the central nervous system, which occurs in immunosuppressed individuals. I... Koralnik,J Igor - 《Current Opinion in Neurology》 被引量: 247发表: 2004年 The role of SVZ-derived neural precursors in demyelinating diseases...
West Nile encephalitis - encephalitis caused by the West Nile virus; can be fatal in humans and horses and birds Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc. Translations Spanish / EspañolSelect a language: encephalitis [ˌensefəˈla...
induced. We have thought long and hard as to a precise definition of demyelination and cannot do better than my mentor, Professor Raymond Adams, who we quote above. In demyelinating disease, myelin is specifically affected by a peculiar pattern of myelin lysis, the mechanisms of which are ...
In humans, the diagnosis and the characterization of the nystagmus have major clinical implications because it represents a predictive symptom of major central nervous system pathologies, including multiple sclerosis or Pelizaeus-Merzbacher disease10,11,12,13. Nystagmus is also encountered in specific ...
Demyelinating pseudotumor in systemic lupus erythematosus: A case report and literature review. Demyelinating pseudotumor (DPT) is an inflammatory demyelinating disease in central nervous system, and the main pathological change is demyelination, whic... Y Chen,L Li,M Gui - Zhong nan da xue xue ba...
However, there are many phenotypic variants, suggesting that CIDP may not be a discrete disease entity but rather a spectrum of related conditions. While the abiding theory of CIDP pathogenesis is that cell-mediated and humoral mechanisms act together in an aberrant immune response to cause damage...
In CIDP, the autoimmune attack is directed toward peripheral nerves and nerve roots. Only about one-third of children with CIDP can point to an inciting or antecedent event in the months prior to disease onset.12–14 Even among children with an acute inflammatory neuropathy such as Guillain-...
The initial clinical symptoms became apparent in October 2002. Arrows indicate confirmed clinical relapses; EDSS, Expanded Disability Status Scale; and stars, time points when the frequencies of B lymphocytes were analyzed. Neuroimaging and therapy data Disease activity was monitored by frequent MRI ...