2006. Further investigation of the N-demethylation of tertiary amine alkaloids using the non-classical Polonovski reaction. Bioorg Med Chem Lett 16(11); 2868-2871.S. Thavaneswaran, P.J. Scammells, Further investigation of the N-demethylation of tertiary amine alkaloids using the non-classical ...
The tricyclic antidepressant (TCA) tertiary amines imipramine (IMI) and amitriptyline (AMI) were found, soon after their introduction as drugs, to have active demethyl metabolites—desipramine (DMI) and nortriptyline (NT) (figure 1). These two secondary amines were later introduced as ...
A domain found within a superfamily of proteins that are characterized by their β-barrel tertiary structure (in Latin, cupa means small barrel). Proteins containing this domain include metal coordinating oxygenases and other proteins that lack enzymatic activity. Oxoferryl High-valent oxoiron (IV)...
organo‐palladium compoundso-N,N-Dimethylaminotoluene (dmat) reacts with Li 2PdCl 4 in methanol to give trans-Pd(mat) 2Cl 2 (mat = o-N-methylaminotoluene) by demethylation of the nitrogen. With Pd(PhCN) 2Cl 2 in dichloromethane an unstable dimeric adduct of the tertiary amine is ...
Thavaneswaran et al., “Further Investigation of the N-Demethylation of Tertiary Amine Alkaloids Using the Non-Classical Polonovski Reaction”; Bioorganic and Medicinal Chemistry Letters; 16(11); (2006); pp. 2868-2871.Shanti Thavaneswaran,Peter J. Scammells.Further investigation of the N-...
The parent compound is charged on the column, and the neat N-demethylated secondary amine leaves the column some minutes later.Thomas RosenauInstitute of ChemistryAndreas HofingerInstitute of ChemistryAntje PotthastInstitute of ChemistryPaul Kosma
The tertiary amine is reacted with ethyl chloroformate to form a urethan, which is cleaved to a secondary amine. This is transformed to heptafluoro-butyramide, which makes quantitative determination with electron capture detection possible. The yields of the secondary amines for two tertiary amines ...
8 Finally, tertiary amine displacement has been achieved by nucleophilic attack of lithium aluminumGaryDepartmentH.DepartmentPosnerDepartment&DepartmentJen-ShanDepartmentTingDepartmentInformaworldSynthetic CommunicationsG. H. Posner and J.-S. Ting, Synth. Commun. , 4 , 355 (1974)....
The aim of this study was to examine whether cultured rat thoracic aortic endothelial cells (TAECs) have the ability to metabolize the tertiary amine, imipramine. In rat TAECs, imipramine was biotransformed into N-demethylate and N-oxide by cytochrome P450 (CYP) and flavin-containing ...
A domain found within a superfamily of proteins that are characterized by their β-barrel tertiary structure (in Latin,cupameans small barrel). Proteins containing this domain include metal coordinating oxygenases and other proteins that lack enzymatic activity. ...