Because of the frequency of missed and delayed dementia diagnoses in usual clinical practice,43 claims and registry data from such studies of prevalent dementia are likely to identify hospitalizations predominantly during middle and later stages of cognitive decline. Studies relying on claims data to ...
In the early stages of AD, neuronal COX-2 expression is increased, but this expression declines as the disease advances. This suggests that any possible benefit of COX-2 inhibition might be confined to a very early therapeutic window—long before significant pathology emerges. To date, early int...
In the picturebooks, dementia brings about changes to both the grandparent and family life and the narratives chart the way both the family and child adapt, cope and come to terms with the effects of the condition. As the peritexts in Grandma explain, “People can still live well with ...
Frédéric, BlancSean, J. CollobyNathalie, PhilippiXavier, de PétignyBarbara, JungCatherine, DemuynckClélie, PhillippsPierre, AnthonyAlan, ThomasFabrice, Bing
Estimates in CFAS I are less precise due to the sampling design and therefore smaller numbers in the assessment stages. Incidence rates in CFAS I and II for six 5 year age groups are shown in Fig. 2. The reduction in incidence is calculated as an incidence rate ratio (IRR) 0.8 (95...
The line chart depicts cumulative area under the curve (AUC) values (right axis) as metabolites are included in successive iterations. The metabolites ultimately selected for MetRS calculation are highlighted in red. B Individual SHAP values of the selected metabolites are ranked according to their ...
As participants will be in the early stages of dementia, loss of capacity to consent during the course of participation is expected to be infrequent. However, on entry to the trial participants will be asked whether, should they lose capacity to consent, they are willing to continue to be ...
Radar chart depicts the percent of cases with moderate or severe BPSD subtypes, stratified by Braak NFT stages (0-VI). Cases included for this chart were selected among participants (n = 212) that lacked neocortical LBs and also lacked LATE-NC stage > 1. The UDS parameters utilize...
The advanced disease stage had a significant negative impact on parents’ quality of life due to the high level of impairment their child was suffering, the physicality of heavy caregiving demands, coupled with minimal feedback from their child [62]. Challenging symptoms in the advanced stages inc...
Such discussions ensured reliability and occurred at selection and synthesis stages. Independent advice from co-authors (BW & GM) occurred on five occasions; one related to study selection, three in relation to concept synthesis and one regarding instrument mapping. Three reviews were conducted using...